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VCL activates KCNH2. 9 / 9
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"To compare the rate of recovery from inactivation between the two channels, we used a protocol used in prior I hERG studies : a 500-ms depolarisation to +40 mV was applied from a holding potential of -80 mV to activate and inactivate I hERG."
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"We then used a conventional voltage step protocol, comprised of a 2-second depolarization to +20 mV followed by repolarization to -40 mV to elicit I hERG tails."
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"HERG currents were activated by a 4.8-s depolarizing pulse to + 20 mV from a holding potential of - 80 mV, and the tail current was recorded at - 60 mV."
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"The hERG channels were then activated by applying a depolarising step to + 40 mV for 5 s and then clamped at - 50 mV for 4 s to elicit the hERG tail current, before returning to - 80 mV for 0.3 s. Tes[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"After an initial depolarising command to +40 mV to activate and inactivate I hERG, brief (2 ms) repolarising commands to a range of membrane potentials (in 10 mV increments down to -140 mV) were used to alleviate I hERG inactivation to differing extents and then the amplitude of the rapid I hERG transient during the third step (to +40 mV) was measured."
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"Briefly, a three pulse protocol was used as follows : The pulse comprises a holding potential of -80 mV and a 2-sec pulse to +60 mV to activate and inactivate the hERG channels, followed by a hyperpolarized pulse to -100 mV for 10 msec to recover from inactivation."
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"The hERG currents were elicited by a 3-second depolarizing step in 10 mV increments from -60 mV to 40 mV, from a holding potential of -80 mV, followed by a 3-second step to -50 mV record tail current."
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"To assess the inactivation time course of hERG currents, cells were depolarized from a holding potential of aeuro " 80 mV to +60 mV for 2 s, hyperpolarized to aeuro " 100 mV for 10 ms to allow the hER[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, protriptyline inhibits HERG channels predominantly in the open and inactivated state rather than in the closed state.To examine the use-dependence of the protriptyline effect, HERG cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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