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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ETV6 binds IGF1R, IRS1, and NTRK3. 2 / 2

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"Further work by the same team has revealed that ETV6–TRKC binds to the IGF1R–IRS1 complex at the plasma membrane; this interaction promotes the recruitment of Src, with consequent activation of the PI3K–AKT signalling cascade and upregulation of MAPK activity and cyclin D1 expression xref ."

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"Of interest, ETV6-NTRK3 forms a tripartite complex with phosphorylated IRS1 and IGF1R that seems to be critical for the oncogenic action of the chimera."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...