IndraLab

Statements

USP7 decreases the amount of PML. 3 / 3
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reach
"The observations that USP7 promotes PML ubiquitylation and negatively regulates PML levels were counter intuitive since USP7 generally stabilizes its target proteins by removing their ubiquitin moieties."
21305000
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"Contrary to observations with other targets of USP7, we found that USP7 negatively regulates PML levels and PML-NBs by a mechanism that is independent of its catalytic activity and independent of the previously described PML regulators CK2 and RNF4."
21305000
reach
"Silencing of USP7 caused an increase in PML levels even in the absence of p53 (XREF_FIG), indicating that the ability of USP7 to modulate PML levels is independent of p53."
21305000