IndraLab

Statements

GRK5 phosphorylates NPM1 on S4. 5 / 7
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rlimsp
"GRK5 phosphorylates NPM1 at Ser-4, a site shared with PLK1, suggesting the possibility of an interplay between GRK5 and PLK1, in the regulation of NPM1."
27326393
rlimsp
"GRK5 interaction with NPM1 is mediated by the N-terminal domain of each protein, and GRK5 primarily phosphorylates NPM1 at Ser-4, a site shared with polo-like kinase 1 (PLK1)."
22467873
rlimsp
"Taken together, our results demonstrate that GRK5 phosphorylates Ser-4 in nucleophosmin and regulates the sensitivity of cells to PLK1 inhibition."
22467873
reach
"GRK5 interaction with NPM1 is mediated by the N-terminal domain of each protein, and GRK5 primarily phosphorylates NPM1 at Ser 4, a site shared with polo like kinase 1 (PLK1)."
22467873
reach
"GRK5 phosphorylates NPM1 at Ser 4, a site shared with PLK1, suggesting the possibility of an interplay between GRK5 and PLK1, in the regulation of NPM1."
27326393