IndraLab

Statements

NPM1 is phosphorylated on S4. 5 / 32
4 | 5 23
sparser
"An in vitro kinase assay showed that phosphorylated-NPM at Thr199 by CDK1 enhanced NPM phosphorylation at Ser4 by PLK1 as revealed by Western blotting with the phospho-specific NPM antibodies ( xref )."
27619510
sparser
"NPM phosphorylation at Ser4 and Thr199 may play a role in maintaining or generating the structure of the nucleolus."
27619510
sparser
"We detected phosphorylation of NPM1 at serine 4 and serine 10 in three out of four DMSO-treated samples and in none out of five neratinib-treated samples, suggesting a potential role in the induction of apoptosis with neratinib treatment."
35967296
sparser
"Thr199 and Ser4 of NPM are phosphorylated by G2/M checkpoint kinase CDK1 xref and polo-like kinase PLK1 xref , respectively."
27619510
sparser
"These results suggest that phosphorylation of NPM at Ser4 and Thr199 plays a role in determination of nucleolar number."
27619510