IndraLab

Statements

CYLD binds WHAMM. 8 / 8
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"Meanwhile, two amino-terminal cytoskeleton-associated protein glycine-rich (CAP-Gly) domains of CYLD interact with the astral microtubules and increase their stability [ xref ]."
31795161
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"If the basic side chain contributes significantly to MT binding, then CYLD may not interact with microtubules; however, β-tubulin, as well as Cdc37 and Hsp90, reportedly exists in the IKK complex (Ch[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15341735
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"Given that the extreme N-terminal CAP-Gly domain of CYLD is essential for its interaction with microtubules 17-19 , the above data indicate that the effect of CYLD on noscapine activity is dependent on the binding of CYLD to microtubules and is independent of its deubiquitinase activity."
25897332
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"Although the conserved CAP-GLY domains provide structural basis for the interactions of CYLD with microtubules and many other proteins, an interesting finding is that EB1 containing a known CAP-GLY domain-interacting motif interacts with the C-terminal USP domain of CYLD other than the CAP-GLY domains, implicating a previously unknown role for the USP domain in mediating protein-protein interactions."
28881612
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"CYLD interacts with microtubules primarily through its extreme N-terminal cytoskeleton associated protein glycine-rich (CAP-Gly) domain 17-19 ."
25897332
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"For example, the cytoskeleton-associated protein-glycine-rich domain mediates the interaction of CYLD with microtubules, whereas calponin homology domain mediates the interaction of EB1 with microtubules. xref , xref , xref In this study, using a combination of taxol-based microtubule isolation and mass spectrometry, we have identified a list of proteins that may potentially associate with microtubules."
26445615
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"In agreement with the role of the extreme N-terminal CAP-Gly domain in mediating CYLD interaction with microtubules, immunoblotting revealed that a significant proportion of CYLD, but not its ΔCG1 mutant, was present in the microtubule pellet fraction (Figure xref A)."
25897332
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"The DUB CYLD can associate with microtubules through a CAP-Gly domain, regulate their dynamics, and control entry into mitosis ( xref ; xref ; xref ), whereas a ubiquitin C-terminal hydrolase, UCHL1, has also been found associated with microtubules in certain cell types ( xref )."
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