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Resveratrol inhibits NLRP3. 83 / 83
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"We also found that resveratrol attenuated NLRP3 associated caspase-1 expression and IL-1beta secretion in ox-LDL-activated platelets."
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"Furthermore, Misawa et al. [XREF_BIBR] found that resveratrol might block the assembly of NLRP3 on endoplasmic reticulum and ASC on mitochondria, thereby inhibiting the activation of NLRP3 inflammasome."
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"However, NLRP3 could also be inhibited by glyburide, dioscin, metformin and resveratrol, preventing the bone loss from the progress of pyroptosis."
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"Furthermore, resveratrol offers myocardial protection against CIH-induced damage by targeting Nrf2 and inhibiting the activation of the NLRP3 inflammasome[117]."
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"Resveratrol, at 5 μM, inhibited assembly and activation of NLRP3 inflammasome in stimulated macrophages [153]."
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"In arthritis rat models, resveratrol inhibits the activation of NLRP3 inflammasomes by inducing the PINK1/Parkin-dependent mitophagy (Fan et al., 2021)."
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"Some studies indicate that resveratrol can inhibit the activation of the NLRP3 inflammasome and the subsequent inflammatory response in ischemic stroke [17,111]."
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"Resveratrol (Res), which is a natural polyphenolic compound, inhibits LPS- and ATP-activated NLRP3 inflammasome and protects microglial cells upon pyroptosis."
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"On the other hand, resveratrol and vitamin C have been shown to reduce ROS production and NLRP3 inflammasome activity in mouse lung tissue and macrophages, respectively [XREF_BIBR, XREF_BIBR]."
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"Research has shown that resveratrol inhibits the RAC-alpha serine/threonine-protein kinase (AKT1) and NLRP3 inflammasome in cardiomyocytes caused by acute sympathetic stimulation (Wang et al., 2022)."
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"Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation."
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"Resveratrol (RSV), an activator of Sirt1, reduces inflammatory response and alleviates traumatic brain injury (TBI) by activating Sirt1 to reduce ROS production and inhibit NLRP3 activation (Zou et al., 2018)."
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"Resveratrol down-regulates NLRP3 inflammasome components in varicocelized rats."
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"MSU can damage mitochondria and activate NLRP3, while resveratrol can promote mitophagy via the Parkin/Pink1 pathway and inhibit NLRP3 activation [136] ."
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"The administration of resveratrol significantly decreased prostate weight and expressions of NLRP3, IL-1β, IL-18, and Ki-67 (all p < 0.05)."
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"It was also demonstrated that after CIH stimulation, resveratrol mediated the blockade of NLRP3 inflammation through the activation of AMP-activated protein kinase (AMPK) and could inhibit mTOR/TTP/NLRP3 mRNA signaling [156]."
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"Resveratrol, known for its antioxidant and anti-aging properties, inhibits LPS- and ATP-activated NLRP3 inflammasome signaling, thereby protecting microglial cells from oxidative stress and mitigating[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Metformin and resveratrol could suppress dynamin‐related protein 1 activity and prevent activation of the NLRP3 inflammasome by limiting ER stress to reverse the damage process and protect mitochondrial integrity."
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"Resveratrol inhibits the NLRP3 inflammasome and inflammatory reactions in different cell types involved in ischemic heart disease and prevents the progression of ischemic heart disease to HFrEF (Feng et al., 2020)."
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"Resveratrol also reduced MC and NLRP3 inflammasome activation, which was consistent with the effects of cromolyn sodium."
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"22 However, further research is required to determine whether its role in cardiovascular disease is mediated by effects on NLRP3 inflammasome and/or IL-1 signaling.23 Resveratrol has been shown to inhibit NLRP3 inflammasome activity, reduce TGF-β1 production, and downregulate p-SMAD2/SMAD2 expression in the heart, leading to improved cardiac function and reduced myocardial fibrosis.24 Muscarinone has been found to exert a beneficial effect on cardiac function in mice post-myocardial infarction by suppressing chronic inflammation mediated by cardiac macrophages."
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"[65] Polyphenolic resveratrol indirectly inhibits NLRP3 inflammasome, through suppression of mitochondrial damage and induction of autophagy."
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"For example, resveratrol, by modulating sirtuin 1 activity, was able to inhibit NLRP3 activation and protected against vascular injury in vivo [73]."
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"[65] Polyphenolic resveratrol indirectly inhibits NLRP3 inflammasome, through suppression of mitochondrial damage and induction of autophagy."
| DOI
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"XREF_BIBR showed that the plant polyphenolic compound resveratrol, known to induce autophagy, suppresses mitochondrial damage in macrophages and thereby inhibits NLRP3 inflammasome activation and NLRP3 inflammasome mediated IL-1beta secretion and pyroptosis."
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"Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult."
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"Resveratrol inhibited NLRP3 activation by blocking the signaling of TLR4/MyD88/NF-κB, which may be the mechanism."
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"Yang et al. reported that treatment with resveratrol for 4 weeks decreased the expression NLRP3 inflammasome, IL-1, IL-6, and TNF [214]."
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"A study on cardiac ischemia and hypoxia demonstrated that resveratrol protects against ischemia-induced cardiac injury in mice in vivo by inhibiting NLRP3-mediated inflammasome activation via SIRT1/p53,29 from which we hypothesized that after retinal I/R injury, resveratrol also suppresses the NLRP3 inflammasome pathway by upregulating the activity and expression of SIRT1, thereby alleviating the occurrence of retinal cell scorch death.Müller cells are a kind of macroglia unique to the retina."
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"Our data also provide evidence that resveratrol can attenuate NLRP3 inflammasome in a CIN model, as the level of renal NLRP3 in our CIN group was dramatically reduced by pretreatment with resveratrol in the RCIN group."
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"Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy."
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"Previous studies have shown that resveratrol can suppress NLRP3 and subsequent IL-1beta in sepsis models [XREF_BIBR]."
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"Alternatively, the suppression of NLRP3 cytokine production and ROS by resveratrol in a separate rat TBI model was shown to be sirtuin 1 (SIRT1) dependent, illustrating the pleiotropic manner by which polyphenols suppress NLRP3 mediated neuroinflammation."
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"Resveratrol has been shown to inhibit the accumulation of acetylated α-tubulin and subsequent contact of mitochondria with the endoplasmic reticulum (ER), thus causing insufficient assembly of ASC and NLRP3 in macrophages [39]."
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"Consistent with our results, resveratrol, a natural antioxidant polyphenol compound, was reported to inhibit the NLRP3 inflammasome in macrophages by enhancing autophagy [21] ."
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"Our results demonstrated that resveratrol inhibits LPS- and ATP-activated NLRP3 inflammasome and protects microglial cells upon oxidative stress, proinflammatory cytokine production, and pyroptotic cell death resulting from inflammasome activation."
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"For example, resveratrol reduced the increased NLRP3 and NF-κB expression in the mouse hippocampus and ameliorated the anxiety-like behaviors that were caused by estrogen deficiency ( Liu et al., 2019[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To sum up, our results suggest that resveratrol suppresses the NLRP3 inflammasome and miR-155 expression through AMPK and Sirt1 pathways in microglia."
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"The active form of Resveratrol (RSV) inhibits NLRP3-mediated inflammasome activation by Sirt1 (SIRT1) / p53-dependent cellular aging."
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"134 Resveratrol has been found to inhibit the TLR4/NF‐κB and/or NLRP3 (NOD‐like receptor protein 3) and STAT (signal transducer and activator of transcription) cascade signaling pathways, 135 and to exert anti‐inflammatory effects by suppressing M1 microglial activation."
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"We also found that resveratrol could reduce the NLRP3 inflammasome increase in the ileum and dorsal hippocampus."
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"NLRP3 inflammasome inhibitors such as tranilast, tetracycline, resveratrol, nicardipine, erythropoietin and colchicine are under clinical trials for management of COVID-19 [16]."
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"Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome derived IL-1beta secretion and pyroptosis in macrophages."
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"Resveratrol inhibits the activation step of the NLRP3 inflammasome by suppressing mitochondrial damage."
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"Our data indicate that resveratrol suppresses NLRP3 inflammasome activation by preserving mitochondrial integrity and by augmenting autophagy."
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"Resveratrol pretreatment also inhibited the activation of NLRP3 and caspase-1, and reduced the production of inflammatory cytokines and ROS."
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"Polydatin, a glycoside of resveratrol, can reduce the activation of the NLRP3 inflammasome and then relieve microglial inflammation, which has a neuroprotective effect on SCI (112)."
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"Our previous study revealed that treatment with 3-MA could block resveratrol-mediated inhibition of the NLRP3 inflammasome [ 3 ]."
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"Resveratrol reduces doxorubicin-induced cardiac injury and systemic inflammation through downregulating NLRP3 inflammasomes [259]."
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"One prior study reported that NLRP3 inflammasome in brain was involved in LPS induced depressive like behaviors in mice, and another showed that resveratrol improved the spatial memory of mice with cecal ligation and puncture and inhibited the NLRP3 and IL-1beta axis in microglia."
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"Resveratrol was described to inhibit NLRP1, NLRP3, and NLRC4 activation by preventing mitochondrial damage and augmenting autophagy."
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"Differently, resveratrol, a non-flavonoid phenolic substance, inhibited NLRP3 through launching the Pink1/Parkin pathway to induce mitophagy, attenuating bone loss [122]."
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"In a study, Lagouge et al. (2006) indicated that 10 μM resveratrol inhibited the NLRP3 inflammasome by inducing autophagy through activation of SIRT1."
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"Resveratrol Protects against Sepsis Associated Encephalopathy and Inhibits the NLRP3 and IL-1beta Axis in Microglia."
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"Resveratrol Inhibited the Induction of the NLRP3 Inflammasome Pathway by mCRP and LPS."
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"In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3 and IL-1beta axis in the microglia."
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"Not surprisingly, resveratrol, the polyphenol present in the skin of grapes, another sirtuin activator, also inhibits NLRP3 inflammasome activation in mice by preserving mitochondrial function, and protects against hepatosteatosis, renal inflammation and LPS induced lung injury [XREF_BIBR - XREF_BIBR]."
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"Mechanistically, resveratrol inhibited the TLR4/NF-κB/NLRP3 pathway, attenuated NLRP3 activation and cytokine production, and increased intestinal probiotic levels [89]."
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"Of note, resveratrol has been demonstrated to suppress NLRP3 progression by activating pyroptosis and inhibiting NSCLC inflammasome activation (31)."
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"Previously , we have reported that resveratrol inhibits NLRP3 expression through a TXNIP mediated mechanism ( Ishrat et al ., 2015 ) ."
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"Also, Sui et al. (2016) observed that resveratrol (30 mg/kg) showed protection against sepsis-associated encephalopathy and inhibited the NLRP3/IL-1𝛽 axis in microglia."
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"Moreover, resveratrol was demonstrated to inhibit the NLRP3 and IL-1beta axis at both in vivo and in vitro levels."
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"In vitro experiments showed that in Aβ-induced AD cell model, resveratrol can inhibit TLR4/NF-κB [80]、TXNIP / TRX / NLRP3 signaling and transcription activators [81]."
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"The molecular targeting and therapeutic efficacy of resveratrol depend on the activation of AMPK and SIRT1, inhibiting mTOR, NF-κB, and NLRP3 pathways [46,47]."
36232980
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"Resveratrol, a naturally occurring plant polyphenol compound, has been shown to inhibit the activation of the NLRP3 inflammasome in macrophages by inducing autophagy in a mouse model of progressive IgA nephropathy [XREF_BIBR]."
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"In line with the reduction of ASC specks, paclitaxel augmented NLRP3 inflammasome activation was also inhibited by resveratrol, NAD +, or MEC-17 siRNA knockdown."
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"Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway."
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"Resveratrol was reported to inhibit the NLRP3 inflammasome by reducing the activation of caspase-1 in response to various NLRP3 stimuli [27,28] ."
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"A study demonstrated that in BV2 microglial cell lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1beta cleavage caused by ATP."
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"Furthermore, resveratrol was able to inhibit the activation of the TXNIP/NLRP3 axis both in adipocyte treated with high levels of glucose and in the adipose tissue of streptozotocin-induced diabetic mice through the suppression of ER stress and the inhibition of ROS-associated mitochondrial fission in an AMPK-dependent way, thus preventing high glucose-induced damage [97]."
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"Resveratrol might inhibit NLRP3 activation by the above mentioned mechanisms, but it may also inhibit the NLRP3 and IL-1beta priming via sirt1, since sirt1 might prevent the transcriptional level of IL-1beta [XREF_BIBR]."
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"Our findings demonstrate that resveratrol inhibits the activation of the NF-κB and NLRP3 inflammasomes and reduces the production of inflammatory cytokines."
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"Resveratrol can also inhibit the NLRP3 and IL-1beta axis in hippocampus of SAE mice and microglial cells stimulated by LPS and ATP, which is critical for the development of SAE."
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"Previous studies in different cardiac pathologies have suggested that resveratrol treatment and regular exercise training can inhibit the NLRP3 inflammasome activity and improve cardiac function by af[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol inhibits the NLRP3/IL-1β axis of microglia, reduces hippocampal inflammation, and improves spatial memory in SAE mice (161)."
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"Studies have shown that resveratrol may inhibit the activation of NLRP3 inflammasome via the combination of Sirt1 and Sirt6, thus exerting a series of protective effects on the body (158).4.2.5 Berberine."
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"In animal studies, 25 mg/kg resveratrol significantly downregulated NLRP3 by 0.6‐fold (p < 0.01) [60]."
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"Resveratrol mainly elevates the Siert1 and inhibit the NLRP3 inflammasome to prevent the inflammation (Fu et al., 2013)."
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"Resveratrol and regular exercise significantly decreased nlrp3 mRNA and protein expression, the ratio of cleaved-caspase-1/pro-caspase-1 and mature-IL-1β/pro-IL-1β in the hypertensive group."
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"Research has shown that resveratrol inhibits NLRP3 activation in macrophages by inhibiting mitochondrial damage and enhancing autophagy [93]."
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"In addition, metformin or resveratrol attenuated OGD/R-induced upregulation of TXNIP and NLRP3 activation, whereas SIRT6 deficiency abolished the effects of metformin or resveratrol on the expression of TXNIP and NLRP3 inflammasome signaling (Fig. 6B)."
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"Resveratrol Suppresses Gut Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model."
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"Resveratrol (Bal et al. 2022), purple sweet potato pigment (Wang et al. 2019, Sun et al. 2019), and honokiol (Huang et al. 2020) inhibit endothelial and myocardial senescence by blocking NLRP3 inflammasomes."
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