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Resveratrol inhibits NLRP3. 43 / 43
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"[65] Polyphenolic resveratrol indirectly inhibits NLRP3 inflammasome, through suppression of mitochondrial damage and induction of autophagy."
34957352
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"We also found that resveratrol attenuated NLRP3 associated caspase-1 expression and IL-1beta secretion in ox-LDL-activated platelets."
33728029
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"Not surprisingly, resveratrol, the polyphenol present in the skin of grapes, another sirtuin activator, also inhibits NLRP3 inflammasome activation in mice by preserving mitochondrial function, and protects against hepatosteatosis, renal inflammation and LPS induced lung injury [XREF_BIBR - XREF_BIBR]."
27942750
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"Resveratrol Suppresses Gut Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model."
30670927
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"Alternatively, the suppression of NLRP3 cytokine production and ROS by resveratrol in a separate rat TBI model was shown to be sirtuin 1 (SIRT1) dependent, illustrating the pleiotropic manner by which polyphenols suppress NLRP3 mediated neuroinflammation."
30210334
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"Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway."
34739715
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"[65] Polyphenolic resveratrol indirectly inhibits NLRP3 inflammasome, through suppression of mitochondrial damage and induction of autophagy."
| DOI
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"Resveratrol inhibits the assembly of ASC and NLRP3 60) ."
33678767
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"Metformin and resveratrol could suppress dynamin‐related protein 1 activity and prevent activation of the NLRP3 inflammasome by limiting ER stress to reverse the damage process and protect mitochondrial integrity."
34459122
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"A study demonstrated that in BV2 microglial cell lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1beta cleavage caused by ATP."
29850641
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"In a study, Lagouge et al. (2006) indicated that 10 μM resveratrol inhibited the NLRP3 inflammasome by inducing autophagy through activation of SIRT1."
34760269
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"Our data also provide evidence that resveratrol can attenuate NLRP3 inflammasome in a CIN model, as the level of renal NLRP3 in our CIN group was dramatically reduced by pretreatment with resveratrol in the RCIN group."
30691208
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"Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation."
24629563
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"Our results demonstrated that resveratrol inhibits LPS- and ATP-activated NLRP3 inflammasome and protects microglial cells upon oxidative stress, proinflammatory cytokine production, and pyroptotic cell death resulting from inflammasome activation."
34739715
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"On the other hand, resveratrol and vitamin C have been shown to reduce ROS production and NLRP3 inflammasome activity in mouse lung tissue and macrophages, respectively [XREF_BIBR, XREF_BIBR]."
33430331
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"Furthermore, resveratrol was able to inhibit the activation of the TXNIP/NLRP3 axis both in adipocyte treated with high levels of glucose and in the adipose tissue of streptozotocin-induced diabetic mice through the suppression of ER stress and the inhibition of ROS-associated mitochondrial fission in an AMPK-dependent way, thus preventing high glucose-induced damage [97]."
32650482
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"One prior study reported that NLRP3 inflammasome in brain was involved in LPS induced depressive like behaviors in mice, and another showed that resveratrol improved the spatial memory of mice with cecal ligation and puncture and inhibited the NLRP3 and IL-1beta axis in microglia."
27923741
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"Moreover, resveratrol was demonstrated to inhibit the NLRP3 and IL-1beta axis at both in vivo and in vitro levels."
26924896
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"NLRP3 inflammasome blockade by resveratrol appeared to be mediated by activating AMP activated Protein Kinase (AMPK), which could restrain mTOR/TTP/NLRP3 mRNA signalling."
31996295
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"Resveratrol pretreatment also inhibited the activation of NLRP3 and caspase-1, and reduced the production of inflammatory cytokines and ROS."
29257276
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"Resveratrol Protects against Sepsis Associated Encephalopathy and Inhibits the NLRP3 and IL-1beta Axis in Microglia."
26924896
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"Resveratrol might inhibit NLRP3 activation by the above mentioned mechanisms, but it may also inhibit the NLRP3 and IL-1beta priming via sirt1, since sirt1 might prevent the transcriptional level of IL-1beta [XREF_BIBR]."
26924896
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"To sum up, our results suggest that resveratrol suppresses the NLRP3 inflammasome and miR-155 expression through AMPK and Sirt1 pathways in microglia."
34739715
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"Previously , we have reported that resveratrol inhibits NLRP3 expression through a TXNIP mediated mechanism ( Ishrat et al ., 2015 ) ."
32788447
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"Furthermore, Misawa et al. [XREF_BIBR] found that resveratrol might block the assembly of NLRP3 on endoplasmic reticulum and ASC on mitochondria, thereby inhibiting the activation of NLRP3 inflammasome."
26924896
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"In line with the reduction of ASC specks, paclitaxel augmented NLRP3 inflammasome activation was also inhibited by resveratrol, NAD +, or MEC-17 siRNA knockdown."
30761140
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"In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3 and IL-1beta axis in the microglia."
26924896
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"Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult."
27276511
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"Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy."
25535911
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"Resveratrol inhibits the activation step of the NLRP3 inflammasome by suppressing mitochondrial damage."
25535911
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"Our data indicate that resveratrol suppresses NLRP3 inflammasome activation by preserving mitochondrial integrity and by augmenting autophagy."
25535911
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"Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome derived IL-1beta secretion and pyroptosis in macrophages."
25535911
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"Resveratrol also reduced MC and NLRP3 inflammasome activation, which was consistent with the effects of cromolyn sodium."
30670927
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"Resveratrol, at 5 μM, inhibited assembly and activation of NLRP3 inflammasome in stimulated macrophages [153]."
34439920
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"XREF_BIBR showed that the plant polyphenolic compound resveratrol, known to induce autophagy, suppresses mitochondrial damage in macrophages and thereby inhibits NLRP3 inflammasome activation and NLRP3 inflammasome mediated IL-1beta secretion and pyroptosis."
26594174
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"For example, resveratrol, by modulating sirtuin 1 activity, was able to inhibit NLRP3 activation and protected against vascular injury in vivo [73]."
35204152
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"Resveratrol, at 5 µM, inhibited assembly and activation of NLRP3 inflammasome in stimulated macrophages [153] ."
34439920
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"Previous studies have shown that resveratrol can suppress NLRP3 and subsequent IL-1beta in sepsis models [XREF_BIBR]."
30691208
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"Research has shown that resveratrol inhibits NLRP3 activation in macrophages by inhibiting mitochondrial damage and enhancing autophagy [93]."
32148650
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"Resveratrol was described to inhibit NLRP1, NLRP3, and NLRC4 activation by preventing mitochondrial damage and augmenting autophagy."
28588486
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"Resveratrol down-regulates NLRP3 inflammasome components in varicocelized rats."
29456821
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"Resveratrol, a naturally occurring plant polyphenol compound, has been shown to inhibit the activation of the NLRP3 inflammasome in macrophages by inducing autophagy in a mouse model of progressive IgA nephropathy [XREF_BIBR]."
33854691
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"Resveratrol can also inhibit the NLRP3 and IL-1beta axis in hippocampus of SAE mice and microglial cells stimulated by LPS and ATP, which is critical for the development of SAE."
26924896