IndraLab

Statements

USP1 activates PC. 3 / 3
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"29 3.7 Targeting USP1 promotes PC cell response to therapeutic agent enzalutamide."
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"In addition, inhibition of USP1 decreased PC proliferation and promoted response to therapeutic agent enzalutamide in a KDM4A dependent manner."
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"The supportive evidence is as follows : (i) USP1 knockdown decreased PC cell proliferation in vitro and tumorigenesis in vivo, and promoted the response to therapeutic agent enzalutamide; and (ii) inhibition of USP1 sensitized cancer cells to therapeutic agent enzalutamide, whereas this effect was blunted by overexpression of KDM4A."
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