IndraLab

Statements

EGFR phosphorylates SRC on Y419. 9 / 9
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rlimsp
"However, when the EGFR is continuously activated (Figure 3C), it might phosphorylate Src at Y416 position to activate the downstream signaling pathway."
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reach
"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
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reach
"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site XREF_BIBR."
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rlimsp
"Consistent with previous studies252627, we observed that EGFR autophosphorylation at Tyr1173, Src phosphorylation at Tyr418, tyrosine phosphorylation of β4 integrin, and FAK autophosphorylation at Tyr397 were more prevalent in MDA-MB-231 cells compared to MCF7 cells (Figs 1a and 2a), implying that a tyrosine phosphorylation cascade through EGF/Src-family kinases (SFKs) is associated with β4 integrin/FAK complex formation."
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sparser
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context xref ."
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"The dependency of O 3 -induced EGFR activation on Src activation in HBEC is supported by the findings of O 3 -induced phosphorylation of Src at Y416, the phosphorylation of EGFR at the transactivation site Y845, and the inhibitory effect of Src kinase inhibitors on EGFR phosphorylation."
25303742
rlimsp
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context [58]."
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"Src was not found to be involved in the EGFR activation as indicated by unchanged phosphorylation of Src Tyr 416 and EGFR Tyr 845."
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reach
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context XREF_BIBR."
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