IndraLab

Statements

UCHL5 activates TGFB. 9 / 11
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"We show that UCH37 knockdown significantly inhibits the activity of a TGFbeta dependent gene reporter and selectively decreases levels of some TGFbeta dependent target genes, notably p21 and PAI-1, but only during the early phase of TGFbeta receptor activation."
21187158
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"The up-regulation of TGF-beta signaling by UCH37 could also be partly explained by the deubiquitination and stabilization of Smad3 [67,68]."
20302916
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"The up-regulation of TGF-beta signaling by UCH37 could also be partly explained by the deubiquitination and stabilization of Smad3 [32,33]."
23220010
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"In the TGFbeta pathway, UCH37 is capable of deubiquitinating the TGFbeta Type I receptor via a complex that includes Smad7 in mammalian cells and UCH37 activity serves to promote TGFbeta signaling."
18797952
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"In contrast, UCH37 demonstrated a minimal increase in CAGA-Luc activity suggesting that UCH37 may also target the TGF-beta pathway downstream of the TbetaR complex to regulate overall TGF-beta signaling (XREF_SUPPLEMENTARY)."
26435193
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"We have shown that UCHL5 promotes TGFbeta signaling via stabilization of Smad2 and Smad3 and may be a potential therapeutic target to block the differentiation of myofibroblasts and the expression of matrix in IPF."
27604640
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"Finally, AMSH-LP and UCHL5 promote TGF-beta responses through their interaction with inhibitory I-SMADs [XREF_BIBR, XREF_BIBR]."
25972356
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"The DUBs USP4, USP11, USP15, and UCH37 have previously been demonstrated to modulate TGF-beta pathway activity by directly deubiquitinating the TbetaRI, resulting in increased TbetaRI stability (XREF_FIG) XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
26435193
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"In addition, UCH37 stabilizes Smad2/3 and promotes TGF-β1 signal transduction (39)."
35095928