IndraLab

Statements

UCHL5 activates TGFB. 11 / 13
| 11
reach
"The DUBs USP4, USP11, USP15, and UCH37 have previously been demonstrated to modulate TGF-beta pathway activity by directly deubiquitinating the TbetaRI, resulting in increased TbetaRI stability (XREF_FIG) XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
26435193
reach
"In contrast, UCH37 demonstrated a minimal increase in CAGA-Luc activity suggesting that UCH37 may also target the TGF-beta pathway downstream of the TbetaR complex to regulate overall TGF-beta signaling (XREF_SUPPLEMENTARY)."
26435193
reach
"Finally, AMSH-LP and UCHL5 promote TGF-beta responses through their interaction with inhibitory I-SMADs [XREF_BIBR, XREF_BIBR]."
25972356
reach
"The up-regulation of TGF-beta signaling by UCH37 could also be partly explained by the deubiquitination and stabilization of Smad3 [67,68]."
20302916
reach
"In the TGFbeta pathway, UCH37 is capable of deubiquitinating the TGFbeta Type I receptor via a complex that includes Smad7 in mammalian cells and UCH37 activity serves to promote TGFbeta signaling."
18797952
reach
"The up-regulation of TGF-beta signaling by UCH37 could also be partly explained by the deubiquitination and stabilization of Smad3 [32,33]."
23220010
reach
"Inhibition of UCHL5 destabilizes Smad2 and inhibits the TGF-β pathway (Nan et al., 2016)."
33577811
reach
"UCHL5 knockdown also attenuated the high glucose-decreased TGF-βR1 protein ubiqutination."
23500140
reach
"Similarly, UCHL5 knockdown attenuated TGF-β bioactivity in HEK-293 cells [11] ."
23500140
reach
"We have shown that UCHL5 promotes TGFbeta signaling via stabilization of Smad2 and Smad3 and may be a potential therapeutic target to block the differentiation of myofibroblasts and the expression of matrix in IPF."
27604640
reach
"Conversely, the UCHL5 over-expression increased the TGF-β bioactivity in HEK-293 cells [11] ."
23500140