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IGF1R binds IRS1. 112 / 129
1 6 5 | 3 46 63
sparser
"IGFR subsequently binds IRS-1 to activate the phosphoInositide-3 kinase (PI3K)-protein kinase B (Akt) pathway."
36819699
reach
"Both IGF1R kinase activity and an intact cytoplasmic Y950 residue, the IRS1 docking site of IGF1R, are required, confirming the importance of the IGF1R and IRS1 interaction for EN oncogenesis."
21804605
sparser
"Multiple serine phosphorylation by different kinases abrogates IRS1 binding to IGF1R and interrupts downstream activation of pro-proliferative signaling leading to insulin resistance."
39682211
sparser
"Furthermore, activated IGF1R has been recently shown to translocate to the nucleus in both non-malignant tissues and cancers xref – xref , although it remains to be determined whether IRS1 and IGF1R interact in this subcellular location."
22558377
sparser
"Ligand-activated IGF-1R binds to IRS1, which then binds to the p85 regulatory subunit of PI3K, which then transmits signals to AKT1 and MTOR."
26429980
reach
"Such association with EGFR limited IRS-1 binding to IGF-IR and the activation of the downstream Akt, but treatment with gefitinib shifted IRS-1 back to the IGF-IR signaling."
19030971
trips
"Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10."
8776723
reach
"Our findings can be summarized as follows : (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr 1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR."
7559507
sparser
"Concurrently, the engagement of p85 with ERBB3 and the subsequent interaction between IGF1R and IRS1 further modulates this cascade's progression [ 20 ]."
38608977
reach
"Interestingly, our models do not predict highly ranked recruitment of the insulin receptor substrate 1 (IRS1), a canonical binding partner of INSR and IGF1R [XREF_BIBR, XREF_BIBR]."
30653502
reach
"Although the K D for IRS1 binding to IGF1R is not well established, the PTB domain of IRS1 has an affinity for INSR phosphosites that is approximately 20-fold weaker than that of SHC1 's PTB domain [XREF_BIBR], and protein copy numbers for IRS1 tended to be two to three orders of magnitude lower than those of SHC1 (XREF_SUPPLEMENTARY)."
30653502
reach
"Exposure of VSMC cultures to a peptide that inhibited IRS-1 and IGF-IR interaction showed that IRS-1 binding to IGF-IR impairs SHPS-1 phosphorylation in vivo."
20207740
sparser
"The Akt pathway is initiated by the interaction of IGF-1R with one of its major substrates, insulin receptor substrate-1 that activates PI3K and Akt."
18561945
reach
"Indeed, IRS1 could actually bind IGF1R with extraordinarily strong affinity, in the nanomolar range, as has been reported in one study employing surface plasmon resonance technology [XREF_BIBR]."
30653502
reach
"As expected IGF-I receptor associates strongly with IRS1."
15522217
sparser
"Overexpression or knockdown of TRAF4 affects IRS-1 tyrosine phosphorylation through regulating the interaction between IRS-1 and IGF-1R."
33991522
sparser
"Of note, the adaptor protein IRS1 not only binds to IGF-IR, but also interacts with EGFR/ErbB3."
32493414
sparser
"Interestingly, IGF-1R also constitutively associated with its adaptor protein IRS1, and treatment with osimertinib trended to increase the association of IGF-1R with IRS1 and Gab1, but not EGFR."
32929081
sparser
"Tyrosine phosphorylation of IGF-1R induces the cytoplasmic binding of IRS-1 to IGF-1R and phosphorylation of multiple tyrosine residues in IRS-1."
23432957
reach
"It was shown that IGF-1 stimulation did not affect the binding ability of the alpha-subunits of IGF-1R with the specific antibody.The IRS-1 solution at different concentrations was injected over the I[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
sparser
"Overexpression of TRAF4 enhances IGF1-induced IGFR–IRS-1 interaction, IRS-1 tyrosine phosphorylation, and downstream effector protein activation, whereas mutation of IRS-1 ubiquitination sites completely abolishes these effects."
33991522
reach
"IGFBP-3 and -5 are phosphorylated by DNA-PK [18,27] and IGF-IR/IRS1 complex is important in homologous DNA recombination through Rad51 cell trafficking [28] ."
20188166
sparser
"In this respect, it has been shown that insulin receptor substrate-1 (IRS-1) levels are associated to the IGF-1R inhibitor NVP-AEW541 response [ xref ], independently of the IGF-1R expression levels [ xref ]."
24709958
sparser
"Indeed, S6K activates phosphorylation of insulin receptor substrate 1 (IRS1), thereby leading to IRS1 suppression, or IRS1 degradation, or IRS1 binding to IGF1 receptor."
37596643
reach
"Interestingly, IGF-1R also constitutively associated with its adaptor protein IRS1, and treatment with osimertinib trended to increase the association of IGF-1R with IRS1 and Gab1, but not EGFR."
32929081
sparser
"Next, we investigated whether TRAF4 regulates IGF-1-induced IRS-1 recruitment to IGF-1R. An increased association of IGF-1Rβ with IRS-1 was observed following IGF-1 stimulation."
33991522
sparser
"The absence of this docking site in ETV6-NTRK3 results in its dependence on binding to insulin-like growth factor 1 receptor (IGF1R) and insulin receptor substrate 1 (IRS1) to activate PI3K and transform cells xref , xref ."
32968185
sparser
"TRAF4 overexpression further augmented this interaction ( xref A ), indicating that TRAF4 enhances IGF-1-induced tyrosine phosphorylation of IRS-1 through promoting the interaction between IRS-1 and IGF-1R. The amount of p85 bound to IRS-1 upon IGF-1 stimulation also was significantly increased when TRAF4 is overexpressed, consistent with the level of IRS-1 tyrosine phosphorylation."
33991522
sparser
"As MYO5A-NTRK3 does contain tyrosine 516 of NTRK3, dependence on binding to IGF1R and IRS1 would not be expected."
32968185
sparser
"Firstly, the expression of each IR isoform and its association with IGF-IR or IRS-1 were comparatively analyzed in complicated and non-complicated regions of human plaques by consecutive immunoprecipitations of IRB and IRA isoforms (Fig.  xref )."
29463262
reach
"We show that PKA directly phosphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin phosphatase targeting subunit 1 (MYPT1) to activate PP1 associated with the IGF1R and IRS1 complex."
27856640
sparser
"The Shc proteins mainly interact with the Tyr-950 residue of the IGF-IR, whereas the interaction between the IGF-IR and IRS-1 requires at least two major determinants on the receptor: the Tyr-950 resi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14697248
sparser
"We further knocked down endogenous TRAF4 in MCF-7 cells and found that TRAF4 depletion abolished IGF-1-induced interaction between IGF-1Rβ and IRS-1; the upregulation of IRS-1 tyrosine phosphorylation, including Y612 and Y896 phosphorylation; and the induced association between p85 and IRS-1 compared with the nontargeting control ( xref D )."
33991522
sparser
"Altogether, our results demonstrate that TRAF4-mediated IRS-1 ubiquitination leads to the enhancement of IRS-1 tyrosine phosphorylation through promoting the interaction between IRS-1 and IGF-1R; the phosphorylated IRS-1 in turn binds p85 regulatory subunit of PI3K to activate the downstream effectors ( xref )."
33991522
sparser
"Herein we demonstrated that TRAF4-mediated IRS-1 ubiquitination regulates IRS-1 binding with IGF-1R and subsequent IRS-1 phosphorylation."
33991522
sparser
"Exposure of VSMC cultures to a peptide that inhibited IRS-1/IGF-IR interaction showed that IRS-1 binding to IGF-IR impairs SHPS-1 phosphorylation in vivo."
20207740
sparser
"Another possibility could be that the K29-linked ubiquitin chain conjugated at the K1186 and K1189 sites stabilizes the binding of IRS-1 and IGF-1R. Although the ubiquitination sites are located at the C-terminal end of IRS-1 while its interaction with IGF-1R occurs at the N-terminal PTB domain ( xref ), the spatial distance between the two regions could be close."
33991522
reach
"When IGF-1R binds to IRS1, the latter interacts with the p85 regulatory subunit of P13K, initiating signals to Akt1 and mTOR."
37834454
sparser
"A similar strategy was employed in a separate study, which discovered induction of epithelial-to-mesenchymal transition as a resistance mechanism to KRAS inhibition and highlighted IGFR-IRS1 regulation of PI3K as key to this resistance [ xref ]."
34200676
sparser
"In line with this hypothesis, we have reported that Rab5 determines the interaction between IGFR and IRS-1 xref ."
37528084
sparser
"Possible TNS2-mediated signaling in GIST involving the IGF-1R–IRS-1 and PI3K-AKT pathways seems to be a promising prospect for future studies."
35804982
sparser
"On the other hand, downstream targets of insulin signaling such as IRS1 and IRS2 have been shown to be involved in endometrial proliferation and decidualization of stromal cells ( xref ), specifically the interaction of IRS1 with IGF1R is enhanced by E2 treatment ( xref )."
33749878
sparser
"Our findings can be summarized as follows: (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr-1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR."
7559507
reach
"The dissociation rate constants of the IRS-1 and IGF-1R complexes between the two states of the receptor did not show a significant difference (P = 0.8)."
11557037
reach
"It has been reported recently that gefitinib (an EGFR TKI) inhibits the phosphorylation of IRS1 by IR, but also triggers the association between IRS1 and IGF1R which in turn induces drug-resistance [XREF_BIBR]."
25599599
sparser
"Indeed, previous studies found that PPP1R12A interacted with insulin receptor substrate 1-insulin-like growth factor 1 receptor (IRS1-IGF1R) complex and mediated the process of IRS1 dephosphorylation, promoting PI3K/AKT cascade activation and in turn led to tumor cell proliferation and tumor growth xref , xref ."
34149934
sparser
"We propose that (i) the IGF-IR and the IR share at least in part the same molecular mechanism underlying their interplay with their two substrates, p52Shc and IRS-1, and (ii) IRS-1 interacts with the IGF-IR in a fashion that is different from that used by p52Shc."
7559507
trips
"Our findings can be summarized as follows: (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr-1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR."
7559507
reach
"A number of studies have investigated the interaction between IGF-1R and IRS-1 in vivo using yeast two hybridization and Western blot techniques [11-17]."
11557037
reach
"However, the effect of receptor autophosphorylation level on the affinity of IRS-1 binding to IGF-1R has not been examined."
11557037
trips
"We propose that (i) the IGF-IR and the IR share at least in part the same molecular mechanism underlying their interplay with their two substrates, p52Shc and IRS-1, and (ii) IRS-1 interacts with the IGF-IR in a fashion that is different from that used by p52Shc."
7559507
reach
"In addition, quantitative thermodynamic and kinetic profiles of the binding interaction between IRS-1 and IGF-1R with or without ligand activation have not been determined.Biosensor technology based o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
reach
"After subtracting the sensorgram from the control channel, the binding of IRS-1 to the captured IGF-1R was obtained."
11557037
reach
"The mean values of the association rate constants and dissociation rate constants for the IRS-1 binding to IGF-1R with or without autophosphorylation were obtained from triplicate experiments for each[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
sparser
"For instance, TRAF4 has been reported to mediate IRS1 ubiquitination, regulating IRS1 binding with IGF-1R and subsequent IRS1 phosphorylation, leading to the stimulation of proliferation in breast cancer cells [ xref ]."
38272982
sparser
"Neither was there evidence of interaction between nuclear IGF-1R and the adaptor protein insulin-receptor substrate-1, which can undergo nuclear import ( xref ), but is predominantly cytoplasmic in DU145 cells (not shown)."
20710042
reach
"This is the first time a quantitative kinetic and thermodynamic profile was obtained for the IRS-1 and IGF-1R interaction."
11557037
reach
"Therefore, the effects of Exendin-4 on senescent osteoblasts that we observed were not a consequence of a direct action on GLP-1R, and we speculate that Exendin-4 may play a role through other signali[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31256933
sparser
"Although the K D for IRS1 binding to IGF1R is not well-established, the PTB domain of IRS1 has an affinity for INSR phosphosites that is approximately 20-fold weaker than that of SHC1’s PTB domain [ xref ], and protein copy numbers for IRS1 tended to be two to three orders of magnitude lower than those of SHC1 ( xref )."
30653502
sparser
"Indeed, IRS1 could actually bind IGF1R with extraordinarily strong affinity, in the nanomolar range, as has been reported in one study employing surface plasmon resonance technology [ xref ]."
30653502
sparser
"When IGF-1R binds to IRS1, the latter interacts with the p85 regulatory subunit of P13K, initiating signals to Akt1 and mTOR."
37834454
sparser
"After subtracting the sensorgram from the control channel, the binding of IRS-1 to the captured IGF-1R was obtained."
11557037
sparser
"IGF1R phosphorylation induces the binding of IRS1 to IGF1R, which allows IRS1 to stimulate the PI3K pathway [ xref ]."
32121322
reach
"IGFR subsequently binds IRS-1 to activate the phosphoInositide-3 kinase (PI3K)-protein kinase B (Akt) pathway."
36819699
sparser
"A number of studies have investigated the interaction between IGF-1R and IRS-1 in vivo using yeast two hybridization and Western blot techniques [11–17] ."
11557037
sparser
"However, the effect of receptor autophosphorylation level on the affinity of IRS-1 binding to IGF-1R has not been examined."
11557037
sparser
"In addition, quantitative thermodynamic and kinetic profiles of the binding interaction between IRS-1 and IGF-1R with or without ligand activation have not been determined."
11557037
sparser
"Binding of IRS-1 to the immobilized IGF-1R at different levels of tyrosine phosphorylation can be monitored directly by the SPR biosensor to provide kinetic and thermodynamic information of the intera[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
reach
"Using this patient 's case as a paradigm, we uncover an association between IGF-1R and IRS-1 and ALK signaling."
25173427
sparser
"The mean values of the association rate constants and dissociation rate constants for the IRS-1 binding to IGF-1R with or without autophosphorylation were obtained from triplicate experiments for each[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
sparser
"In a project conducted by Zhao and others, it was observed that the miRNA-targeting activity of C9 is associated with endogenous IRS-1and insulin-like growth factor 1 receptor (IGF1R)."
38552806
sparser
"The IRS-1 solution at different concentrations was injected over the IGF-1R-modified surface for a period of 240 s, followed by washing with HBS buffer, giving a complete association and dissociation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
sparser
"The binding and dissociation of IRS-1 at different concentrations (38.2, 19.1, and 3.64 nM) with the immobilized IGF-1R from IGF-1 activated and unactivated cells are shown in Fig. 5a,b , respectivel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
reach
"We demonstrated that this bias is explained by the inability of LL37 to promote the recruitment of the adapter protein IRS1 to the IGF1R; and by its ability to promote a unique association of IGF1R an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29499305
sparser
"Upon stimulation by IGF-1, IGF-1R binds to IRS-1 and induces its phosphorylation in various cell types ( Li et al., 2009 )."
25540921
reach
"Tyrosine phosphorylation of IGF-1R induces the cytoplasmic binding of IRS-1 to IGF-1R and phosphorylation of multiple tyrosine residues in IRS-1."
23432957
sparser
"The increase in the affinity constant is mainly due to the increase in the association rate constant of IRS-1 binding to activated IGF-1R. The affinity constant values suggest that the intracellular c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11557037
reach
"The Shc proteins mainly interact with the Tyr 950 residue of the IGF-IR, whereas the interaction between the IGF-IR and IRS-1 requires at least two major determinants on the receptor : the Tyr 950 res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14697248
reach
"Our findings indicate that the differential recruitment of IRS1 to the IGF1R serves as a mechanistic explanation for this biased signaling."
29499305
reach
"Considering these features of the beta-arrestins, perhaps they adopt different conformations to recruit different complexes of proteins following stimulation by LL37 versus stimulation by IGF1.Our BRE[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29499305
reach
"As IRS1 recruitment to IGF1R is necessary for the eventual phosphorylation of Akt, this could serve as an explanation for why LL37 does not induce Akt phosphorylation to the extent that IGF1 does."
29499305
sparser
"The interaction of the IGF-I receptor kinase and substrates such as insulin-receptor substrate 1 (IRS-I), a 185 kDa phosphoprotein that is being phosphorylated in response to activation of the IGFq[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8795068
sparser
"The p-IGF-1R/PI3K/Akt/mTOR signaling pathway is induced and activated by the binding of IGF-1R to its ligand leading to autophosphorylation of insulin receptor substrate 1 (IRS-1) [ xref ]."
39718730
reach
"Thus, mTOR inhibitors activate PI3-K and AKT in multiple myeloma cells; activation depends on basal IGF-R signaling; and enhanced IRS-1 and IGF-I receptor interactions secondary to inhibited IRS-1 serine phosphorylation may play a role in activation of the cascade."
16227402
reach
"For instance, TRAF4 has been reported to mediate IRS1 ubiquitination, regulating IRS1 binding with IGF-1R and subsequent IRS1 phosphorylation, leading to the stimulation of proliferation in breast cancer cells [50]."
38272982
reach
"The EGFR-TKI gefitinib reduces the association between IRS1 and EGFR, while promoting the association between IRS1 and IGF-1R, which results in gefitinib resistance [ 31–33 ]."
33894221
reach
"Concurrently, the engagement of p85 with ERBB3 and the subsequent interaction between IGF1R and IRS1 further modulates this cascade's progression [ 20 ]."
38608977
sparser
"Indeed, HRGβ1 treatment reduced the association of IRS-1 with IGF-IR in both cell lines."
21939528
sparser
"In addition, association of the IRS1 positive control with the mutant IGF1R was slightly enhanced."
22693602
reach
"In line with this hypothesis, we have reported that Rab5 determines the interaction between IGFR and IRS-1 ."
37528084
reach
"Ligand activated IGF-1R binds to IRS1, which then binds to the p85 regulatory subunit of PI3K, which then transmits signals to AKT1 and MTOR."
26429980
reach
"Tyrosine phosphorylation of IGF1R induces the binding of IRS1 to IGF1R, and phosphorylation of tyrosine residues in IRS1."
29290648
sparser
"IGF-IR-IRS-1 signaling appears to confer resistance to trastuzimab through upregulation of Skp2, a p27 Kip1 ubiquitin ligase, and subsequent degradation of p27 Kip1 [219] ."
16844299
sparser
"It was found that the two nodes forming the edge IRS1-IGF1R were CA targets; however, IRS1 was upregulated, while IGF1R was downregulated, indicating there may exist complex interactions between CA targets."
35003234
reach
"We show that IRS-1 is recruited to erbB3 following HRGbeta1 treatment in these cells and demonstrate that this novel interaction can serve to reduce the association between IRS-1 and IGF-IR and inhibits signalling via this receptor."
21939528
reach
"Collectively, FOXO1 activation is well correlated with Irs1 trafficking defect and the global decrease of Akt2 and highlights Irs1/Akt2/FOXO1 as an additional altered signaling pathway that participates to the early differentiation defect observed in Hrs-KD cells.Akt2 activation during myoblasts differentiation is mediated by IGFR and Irs1 and is regulated by the small GTPase Rab5a that coordinates the recruitment of Irs1 and IGFR on early endosomes [10, 53]."
34330273
reach
"Moreover, HRGbeta1 stimulation also promoted a significant decrease in association between IRS-1 and IGF-IR in both the MCF-7 and T47D cells, and densitometric analysis revealed this reduction to be statistically significant in both cell lines (P < = 0.01 (n = 3) and P < = 0.05 (n = 3), respectively)."
21939528
reach
"In addition, there was no decrease in association between IGF-IR and IRS-1 following HRGbeta1 stimulation in these cells and, as a consequence, BT-474 cells were excluded from further studies."
21939528
sparser
"Interestingly, the IRS1 gene is a predicted target of miR-370, and the IRS1 protein interacts with IGF1R, which is usually highly expressed in OS [ xref ]."
22550419
sparser
"As expected IGF-I receptor associates strongly with IRS1."
15522217
sparser
"Both IGF1R overexpression and IRS1 overexpression have been associated with breast cancer development, and IGF1R is overexpressed in a majority of breast tumors [ xref ]."
19843326
reach
"Immunoprecipitation and Western blot analysis also revealed that, following treatment of MCF-7 and T47D cells with ABDP, there was a reduced association between IRS-1 and IGF-IR and an enhanced association between IRS-1 and erbB3, as shown in Figure XREF_FIG."
21939528
sparser
"As subsequent molecular profiling identified an ALK rearrangement, the study proposed the IGF-1R–IRS-1 signaling axis as a potential therapeutic focus in ALK+ lung cancer, providing insights for upcoming clinical trials [ xref ]."
38397899
sparser
"The association of IRS-1 with IGF-1R was increased in GM3S −/− vs. WT KCs by 8-fold after insulin stimulation ( xref , 5 th row, lanes 6 vs. 3) and by 6-fold after IGF-1 stimulation ( xref , 5 th row, lanes 7 vs. 4)."
24326453
reach
"Following autophosphorylation the IGF-1R binds the adaptor proteins IRS-1 and IRS-2 which then recruit PI3K leading to activation of the Akt/mTOR pathway."
32941924
reach
"As mentioned previously, another interesting phenomenon noted in these studies is the finding that whilst HRGbeta1 treatment enhanced erbB3-IRS-1 interactions, it also promoted a decrease in the association between IRS-1 and IGF-IR, an effect that was clearly apparent in the MCF-7 and T47D cell lines."
21939528
reach
"Heregulin stimulation of the erbB3 receptor resulted in enhanced binding of IRS-1 to erbB3 and consequently reduced IGF-1-R and IRS-1 interaction."
23816396
sparser
"The interaction of IRS-1 with IGF-1R is also modulated via the binding of a tyrosine phosphatase, Syp."
| PMC
sparser
"Canonical IGF-IR/IRS1 signaling is activated through the binding of IRS1 to phosphorylated IGF-IR, resulting in the activation of the ERK/HIF-1α/NF-κB signaling pathway [ xref ]."
25540073
sparser
"The PI3K pathway was found to be activated in EMT-induced KRAS G12C -mutant cell lines via bypass IGFR–IRS1 pathway signalling, and combining sotorasib with the PI3K inhibitor GDC-0941 blocked AKT activation and suppressed cellular proliferation xref ."
36028717
sparser
"Insulin receptor substrate 1 (IRS1), an adaptor of IGF1R has a crucial role in the signal transduction of IGF1R. Tyrosine phosphorylation of IGF1R induces the binding of IRS1 to IGF1R, and phosphorylation of tyrosine residues in IRS1."
29290648
reach
"Upon stimulation by IGF-1, IGF-1R binds to IRS-1 and induces its phosphorylation in various cell types ( Li et al., 2009 )."
25540921