IndraLab

Statements

CYLD leads to the ubiquitination of IKBKG. 4 / 4
| 4
reach
"CYLD can inhibit NF-kappaB activity by deubiquitinating and inactivating TRAF2 and TRAF6, RIP, NEMO, and the NF-kappaB co-activator BCL-3."
18718859
reach
"The effect appears to be related to inhibition of IKKgamma ubiquitination mediated by cIAP1 rather than to stimulation of IKKgamma deubiquitination by the deubiquitinases A20 and CYLD (cylindromatosis)."
23732909
reach
"CYLD, a deubiquitinating enzyme that targets both M1- and K63 linked ubiquitin chains, is recruited to TNF-RSC to negatively regulate ubiquitinations of RIPK1, TNFR1, NEMO and TRADD to attenuate the NF-kappaB pathway and promote both apoptosis and necroptosis."
27984721
reach
"Expression of CYLD significantly reduced K63 polyubiquitination of NEMO induced by either Tax or TRAF6."
17418100