IndraLab

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Ubiquitin activates USP14. 4 / 5
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"On the substrate-engaged pathway, ubiquitin-dependent activation of USP14 allosterically reprograms the conformational landscape of the AAA-ATPase motor and stimulates opening of the core particle gate 8-10 , enabling observation of a near-complete cycle of asymmetric ATP hydrolysis around the ATPase ring during processive substrate unfolding."
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sparser
"On the substrate-engaged pathway, ubiquitin-dependent activation of USP14 allosterically reprograms the conformational landscape of the AAA-ATPase motor and stimulates opening of the core particle gate 8-10 , enabling observation of a near-complete cycle of asymmetric ATP hydrolysis around the ATPase ring during processive substrate unfolding."
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"Intriguingly, Ub deficiency induced the upregulation of USP14 in mammals (Ryu KY, unpublished data) and Ubp6 in yeast XREF_BIBR, thereby sparing Ub from proteasomal degradation and increasing levels of free Ub in an attempt to reach Ub homeostasis."
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"Ubiquitin promotes the Ubp6 and Usp14 noncatalytic effect [52,56-58]."
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