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ERK phosphorylates STAT3 on S727. 65 / 65
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"STAT3 is also phosphorylated by ERK1/2 on S727, which enhances its transcriptional activity ( xref , xref )."
26664907
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"Recently, we have reported dissociation of ethanol potentiation of Ang II stimulated p42/44 MAPK phosphorylation from p42/44 MAPK dependent phosphorylation of serine 727 of STAT3 in hepatocytes ( xref )."
19560630
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"ERK can also phosphorylate STAT3 at Ser727 [ xref ], but we observed no significant changes in phosphorylated STAT3 levels in our study."
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"It is well known that the STAT3 Ser727 residue is phosphorylated mainly by Erk1/2, p38 MAPK, JNK and mTOR [ xref - xref ]."
24423131
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"Based on our finding that ERK phosphorylates STAT3 on Ser727, we investigated whether Tyr705 phosphorylation of STAT3 is stimulated by galectin-1."
28415760
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"STAT3 can also be phosphorylated at Ser727 by extracellular signal-regulated kinase (ERK), which augments the effect of Tyr705 phosphorylation [ xref ]."
28415760
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"Besides Tyr 705 phosphorylation, STAT3 can also be phosphorylated on Ser 727 by extracellular signal regulated kinase (ERK) in ESCs."
25595304
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"As mentioned above, Erk1/2 phosphorylates Stat3 at Ser 727 residue, whereas Src phosphorylates Stat3 at Tyr 705 residue, the phosphorylation at both residues being necessary for Stat3 activation and subsequent dimerization."
23928694
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"On the contrary, inhibition of ERK pathway at the level of MEK, decreased phosphorylation of STAT3 on Ser727, but had no effect on phosphorylation of STAT3 on Tyr705, despite leptin or NaW treatment."
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"STAT3 can be phosphorylated at Ser727 by mTORC1 or ERK1/2 [ xref , xref ]."
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"FGF and ERK phosphorylates STAT3 at Ser 727 to prime mouse ESCs for neural commitment and to secure a fate toward differentiation by inhibiting JAK and STAT3 induced reprogramming of mouse EpiSCs [XREF_BIBR]."
25595304
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"It is known that ERK1/2 phosphorylates STAT3 at Ser727 in human bladder cells and that STAT3 plays the key role directly downstream from ERK1/2 as an alternative survival pathway in neurons [ xref , xref ]."
32913557
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"In this regard, it has been shown that ERKs phosphorylates STAT3 in Ser 727 [22] ."
14680700
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"MAPKs Erk, but not JNK and p38, phosphorylate serine 727 of STAT3 in vitro and in vivo [ xref ]."
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"It is possible that cicaprost stimulated ERK can directly phosphorylate STAT3 Ser 727 residue by close proximity protein protein interaction."
15979846
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"Cells were treated with the ERK1/2 pathway inhibitor U0126 to further evaluate whether mitochondrial ERK1/2 phosphorylates mitochondrial STAT3 on serine 727."
24582310
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"Phosphorylation of S727 in STAT3 by c-Jun N -terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) may enhance or be required for STAT3/DNA interaction [ xref , xref ] and promote tumorigenesis independently of pY705 [ xref , xref ]."
24662938
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"ERK1/2, mTOR, Vav, Rac-1, and SEK-1 and MKK-4 can all phosphorylate Stat3 at Ser727 depending on extracellular stimulus and cell type."
19997066
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"Inhibition of MEK and ERK with U0126 totally blocked the phosphorylation of STAT3 (Tyr705 and Ser727) but increased the phosphorylation of CREB and ATF1 (XREF_FIG)."
21253577
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"ERK1/2 specifically phosphorylates STAT3 at serine 727, which negatively modulates STAT3 tyrosine phosphorylation [XREF_BIBR]."
28061458
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"Stat3 phosphorylation at S727 by ERK plays a key role in zinc-induced astrogliosis."
34699606
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"It was further demonstrated that nicotine stimulation resulted in an ERK1/2 mediated increase in STAT3 phosphorylation at S727, and this could be reversed by treatment with an ERK inhibitor."
24398389
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"STAT3 can also be phosphorylated at Ser727 by ERK, CDK1, ATM and ATR [ xref ]."
24743777
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"Extracellular signal-regulated kinase (ERK) phosphorylates signal transducer and activator of transcription 3 (STAT3) at Ser727, resulting in inflammation."
35660348
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"Another potential mechanism for inhibition of STAT3 activation is through inhibition of ERK-dependent STAT3 phosphorylation on Ser 727 , which is required for full STAT3 transcriptional activity [ xref ]."
23782265
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"It has also been reported recently that ERKs phosphorylate STAT3 on Ser 727 in vitro as well as in vivo in response to epidermal growth factor (EGF) [35] ."
11960596
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"Recently, serine phosphorylation of Stat3 on Ser-727 by ERK has been identified in response to epidermal growth factor (EGF)."
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"Constitutive Ser727 phosphorylation of STAT3 in lung tumor cells requires EGFR and MEK kinase activity XREF_BIBR, suggesting that Erk1/2 may also contribute to STAT3 Ser727 phosphorylation in this model."
23251519
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"Because ERK1/2 can phosphorylate STAT3 at the Ser727 residue [ xref , xref ], we explored whether CMC2.24 affected STAT3 activation."
29683208
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"We provide in vitro and in vivo evidence that the ERK family of mitogen-activated protein (MAP) kinases, but not JNK or p38, specifically phosphorylate STAT3 at serine 727 in response to growth factors."
9343414
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"Transactivation of JAK2 by IL-6 is the key modulator in phosphorylation of both residues (Y705 and S727) of STAT3, whereas Ucn-stimulated ERK1/2 mainly phosphorylates the S727 residue of STAT3."
31073117
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"STAT3 can be phosphorylated at Ser727 by mTORC1 or ERK1/2 [XREF_BIBR, XREF_BIBR]."
28423521
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"Extracellular signal-regulated kinase (ERK) phosphorylates signal transducer and activator of transcription 3 (STAT3) at Ser727, resulting in inflammation."
35660348
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"These results suggest that STAT3 may be phosphorylated at Ser 727 by Erk1/2."
23115188
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"* IgE-antigen activation of mast cells is followed by ERK1/2 mitochondrial translocation, which phosphorylates mitochondrial STAT3 on serine 727."
24582310
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"STAT3 can also be phosphorylated at Ser727 by extracellular signal regulated kinase (ERK), which augments the effect of Tyr705 phosphorylation [XREF_BIBR]."
28415760
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"FcεRI-dependent mast cell activation is accompanied by Erk1/2-dependent phosphorylation of STAT3 on Ser727 and its translocation to mitochondria."
33178217
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"Previously, it has been shown that STAT3 is phosphorylated at a Ser727 residue by ERK1/2 and CDK5, a unique member of the CDK family [ xref – xref ]."
25038288
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"The Erk1/2 kinases in the cytoplasm of mast cells phosphorylate amino acid residue Serine73 on MITF and amino acid residue Serine727 on Stat3, prompting their translocation to the mitochondria; these two transcription factors in consort with phosphorylated pyruvate dehydrogenase (PDH) exert important regulatory effects on the mast cell intracellular signaling transduction [93, 94]."
36251242
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"Previously, it has been reported that FGF-1 stimulation leads to the activation of ERK1/2, which in turn phosphorylates STAT3 at Ser727 in prostate cancer cells [ xref ]."
21906308
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"Based on our finding that ERK phosphorylates STAT3 on Ser727, we investigated whether Tyr705 phosphorylation of STAT3 is stimulated by galectin-1."
28415760
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"Notably, LMP1, via PKCδ and ERK could also cause phosphorylation of STAT3 at S727."
27458446
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"Moreover, it is known that the STAT3 Ser-727 is phosphorylated by ERK1/2 [ xref , xref ] and that STAT3 is also implicated in the proliferation tumor-derived cell lines [ xref ]."
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"After blockage of P2Y (1) receptor and deprivation of oxygen-glucose-serum, AG490 (inhibitor of JAK2) reduced phosphorylation of STAT3 (Ser727) as well as expression of GFAP; LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), decreased phosphorylation of Akt and CREB; the inhibitor of mitogen activated protein kinase kinase1/2 (MEK1/2) U0126, an important molecule of Ras and extracellular signal regulated kinase (ERK) signaling pathway, decreased the phosphorylation of JAK2, STAT3 (Ser727), Akt and CREB."
18668152
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"Cells were treated with the ERK1/2 pathway inhibitor U0126 to further evaluate whether mitochondrial ERK1/2 phosphorylates mitochondrial STAT3 on serine 727."
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"Thus phosphorylation of serine 727 in STAT3 by ERK dependent and ERK independent pathways negatively modulates tyrosine phosphorylation resulting in the inhibition of dimerization, nuclear translocati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15081531
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"ERK1/2 specifically phosphorylates STAT3 at serine 727, which negatively modulates STAT3 tyrosine phosphorylation [ xref ]."
28061458
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"It has also been reported recently that ERKs phosphorylate STAT3 on Ser 727 in vitro as well as in vivo in response to epidermal growth factor (EGF) [35]."
11960596
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"The mechanism of inhibition proposed indicates that inhibition of TKT by sugiol imply ROS-mediated ERK activation and ERK activated phosphorylates STAT3 on Ser727 and recruits a protein tyrosine phosphatase MEG2, which dephosphorylates STAT3 on Tyr705 leading to the inhibition of STAT3 [59]."
30065158
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"Besides Tyr 705 phosphorylation, STAT3 can also be phosphorylated on Ser 727 by extracellular signal-regulated kinase (ERK) in ESCs."
25595304
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"Moreover, it is known that the STAT3 Ser 727 is phosphorylated by ERK1/2 [XREF_BIBR, XREF_BIBR] and that STAT3 is also implicated in the proliferation tumor derived cell lines [XREF_BIBR]."
23902727
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"It is possible that cicaprost-stimulated ERK can directly phosphorylate STAT3 Ser 727 residue by close proximity protein–protein interaction."
15979846
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"Our results showed that everolimus activated Erk and p38 MAPK and phosphorylated STAT3 at Ser727, which SB203580 inhibited phosphorylation of STAT3 at Ser727 (Figures  xref and xref )."
24423131
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"PERK1/2 can phosphorylate STAT3 at serine 727 (S727) because it has serine/threonine kinase activity and might interact with the JAK/STAT pathway in this way."
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"Phosphorylation of the transcription factor STAT3 on Ser 727, mediated by the extracellular signal regulated kinase MAP kinase pathway, may contribute to the decrease in both Bax and Fas expression in p38 alpha-/- cells."
14617800
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"In this regard, it has been shown that ERKs phosphorylates STAT3 in Ser 727 [22]."
14680700
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"Consistent with this suggestion is that ERK, which has been shown to phosphorylate STAT3 at serine 727, was robustly activated in the mitochondria upon NGF treatment (XREF_FIG)."
21738764
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"BM-MSC-induced upregulation of LIF and LIFR in HM20 cells activates ERK, which enhances STAT3 phosphorylation at S727."
33262462
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"STAT3 can also be phosphorylated at Ser727 by ERK, CDK1, ATM and ATR [XREF_BIBR]."
24743777
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"Taken together, these observations suggest that galectin-1-dependent modulation of doxorubicin resistance is enhanced by survivin via ERK-induced STAT3 Ser727 phosphorylation, at least in the cell lines examined here."
28415760
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"It is well known that the STAT3 Ser727 residue is phosphorylated mainly by Erk1/2, p38 MAPK, JNK and mTOR [XREF_BIBR - XREF_BIBR]."
24423131
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"As mentioned above, Erk1/2 phosphorylates Stat3 at Ser 727 residue, whereas Src phosphorylates Stat3 at Tyr 705 residue, the phosphorylation at both residues being necessary for Stat3 activation and subsequent dimerization."
23928694
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"Previously, it has been shown that STAT3 is phosphorylated at a Ser727 residue by ERK1/2 and CDK5, a unique member of the CDK family [XREF_BIBR - XREF_BIBR]."
25038288
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"STAT3 is also phosphorylated by ERK1/2 on S727, which enhances its transcriptional activity."
26664907
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"As a result of the decrease in c-Src phosphorylation, downstream ERK signaling is attenuated, and ERK-induced STAT3 Ser727 phosphorylation is decreased."
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