IndraLab

Statements

USP11 decreases the amount of KLF2. 3 / 3
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"USP11 stabilizes p53 by deubiquitination and inhibits KLF2 expression in microglial cells."
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"The above results convinced us that USP11 could deubiquitinate and stabilize p53 in microglial cells to repress KLF2 transcription."
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"As reflected by western blot and qRT-PCR assays, USP11 knockdown led to upregulated expression of KLF2, as well as downregulated levels of NF-κB (p65), its phosphorylation (p-p65), and downstream markers of the NF-κB pathway (cyclinD1, c-myc) in the brain tissues of rats with ICH-like symptoms; these effects of USP11 knockdown alone could be reversed by its combination with either p53 overexpression or KLF2 knockdown (Figure 5A)."
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