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EGF activates AKT1. 39 / 83
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"It is unknown whether C. elegans LIN-3 and EGF signaling activates PI3K (AAP-1, PDK-1, and AGE-1 in C. elegans) or Akt (AKT-1 and AKT-2 in C. elegans); however, Insulin and IGF Signaling (IIS) has been implicated in regulating longevity through PI3K and Akt [XREF_BIBR]."
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"Binding of TGFα or EGF to EGFR promotes the activation of selected pathways: Ras/RAF/MAPK, PI3K/Akt-1, and signal transducer and transcription-activating (STAT) pathways [42,43,44,45]."
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"Interestingly, it suppressed EGF-induced pAkt and pERK1/2 signaling pathway activation [14]."
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"EGF activates AKT1 ( xref ) and PTN11, the protein tyrosine phosphatase non-receptor type 11 also known as PTP2C ( xref )."
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"In heat-shocked cells, PKBalpha was activated to a certain level without phosphorylation on Thr-308 in the activation loop and on Thr-450 and Ser-473 in the carboxyl-terminal end region, which is critical for growth-factor-induced activation of PKBalpha."
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"In rat liver epithelial cell lines, application of EGF activates the MAP kinase pathway resulting in Cx43 hyperphosphorylation on Ser255, 279 and 282 in the C-terminus of Cx43."
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"Moreover, ablating alpha6beta4 integrin function in the T4-2s by expressing the dominant negative beta4Deltacyto, reduced both basal (XREF_FIG) and EGF stimulated (XREF_FIG D) RAC activity, and overexpression of beta4WT in the S-1 cells led to an increase in both basal (XREF_FIG) and EGF stimulated RAC activity (XREF_FIG C)."
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"Consistent with previous publication [XREF_BIBR, XREF_BIBR, XREF_BIBR], knockdown of AR suppressed EGF induced up-regulation of AKT1 and AKT2 in HepG2 cells."
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"Half-maximal activation of PKBalpha and inhibition of GSK3 by insulin occurred within 2 min with a maximal effect after 5 min and, like the stimulation of glucose uptake and glycogen synthesis, the ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, while LY294002 inhibited Akt-1 activation by EGF, neither FTI nor RhoB-GG were effectual in blocking this activity (see Fig. 4A )."
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"Instead, the cytoplasmic tail of beta4 integrin is necessary for basal and epidermal growth factor induced RAC activity, and RAC mediates tumor survival."
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"We found that Akt-1 activation by oncogenic Ras or EGF could be disrupted by FTI treatment in COS kidney and MCF7 breast epithelial cells, respectively."
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"This difference did not reflect a deficit in the ability to block Akt-1 when it is stimulated by EGF, because both FTI and RhoB-GG could suppress EGF stimulated activation of Akt-1 in MCF7 or Panc1 ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"There is growing evidence that epidermal growth factor (EGF) activates Akt and protein kinase B (PKB) in a phosphoinositide 3-OH kinase (PI3K)-dependent manner, but it is not yet clear which Akt isoforms are involved in this signal transduction pathway."
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"TGFbeta-1, EGF, HGF, bFGF all stimulated significantly increased expression of both COX-2 mRNA and Akt1 mRNA (XREF_FIG)."
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"Binding of ligands (epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha)) to their receptors initiates several signal transduction cascades, specifically the mitogen activated protein kinase (MAPK), protein kinase B (Akt), and c-Jun N-terminal kinase (JNK) pathways, resulting in DNA synthesis and cell proliferation [XREF_BIBR]."
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"Overall, EGF seems to activate AKT1 in rat but PTN11 in human and GSK3 seems active in both organisms."
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"For example, T4-2s that express high alpha6beta4 integrin also have increased basal and EGF induced RAC activity relative to S-1s (XREF_FIG, compare specific activity of RAC in T4-2 with S-1; and XREF_FIG, EGF stimulated RAC activity)."
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"The insulin and EGF induced activation of PKBalpha and the insulin induced inhibition of GSK3 in adipocytes were unaffected by rapamycin but prevented by wortmannin (data not shown), indicating that, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of DNM2 in the NME1 overexpressing cells restored EGF stimulation of pAkt (Fig. 4F)."
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"We assayed for RAC activity and determined that both basal and EGF induced RAC activity significantly correlated with levels of expressed and ligated alpha6beta4 integrin."
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"While pEGFR, pAKT, and ppMEK were all significantly increased by EGF stimulation, no significant increase was detected in RAF‐RBD pulldown of RAS for either mutant (Fig 4A and B)."
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"Whereas insulin induced a greater than 10-fold activation of PKBalpha that was sustained for at least 1 h, EGF only induced a 3-fold activation of PKBalpha which peaked after 2 min and returned to nea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, EGF induced co-immunoprecipitation between PKCzeta and Akt2, but not Akt1, suggesting that a direct interaction between PKCzeta and Akt2 in chemotaxis."
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"EGF activates AKT1 and PTN11, the protein tyrosine phosphatase non receptor type 11 also known as PTP2C."
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"These findings supported the idea that EGF signaling from the germline cells produces a differential of Rac- and Rho-activities across the cyst cells that, perhaps by organizing the actin cytoskeleton, leads to the directional growth of the cyst cells around the germline cells."
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"In this study, we observed that both Ang II and EGF could increase the phospohorylation of EGFR and protein kinase B (AKT)/extracellular signal regulated kinase (ERK), and then induce cell hypertrophy in H9c2 cells."
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"We found that Akt-1 activation by oncogenic Ras or EGF could be disrupted by FTI treatment in COS kidney and MCF7 breast epithelial cells, respectively."
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"RBD-Mutant p110α Expression Inhibits EGF-Induced AKT and RAC Activation."
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"Interestingly, direct analysis of primary SOS1/2 KO primary MEFs has shown that single ablation of either SOS1 or SOS2 did not impair the overall level of EGF-dependent RAC activation, whereas combined SOS1/2 depletion significantly reduced the levels of RAC activation [ xref ], suggesting functionally redundant contributions of SOS1 and SOS2 with regards to RAC activation after EGF stimulation [ xref ]."
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"For example, EGF simulation induces activation of protein kinase B (PKB and Akt) via PIPs, which have multiple functions including antiapoptotic properties."
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"We found that in MECs, EGF stimulation of RAC depends almost entirely on LM ligation of a full-length alpha6beta4 integrin."
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"Because ligand stimulated IGF-IR cells are not motile, we examined the effects of Akt1 or -2 overexpression on parental MCF-10A cells treated with EGF, which induces robust migration and strong activation of ERK."
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"Our conclusion is supported by the following lines of evidence: (1) FBXW2 binds to β-catenin under physiological conditions, and FBXW2-β-catenin binding is dependent on an evolutionarily conserved FBXW2 consensus binding motif (TSMGGT) on β-catenin (Fig.  xref ); (2) FBXW2 ectopic expression or siRNA knockdown decreases or increases the levels of total and phosphorylated β-catenin (β-catenin pS552 ), and β-catenin transcriptional activity, respectively (Fig.  xref ); (3) FBXW2 ectopic expression or siRNA knockdown shortens or extends the protein half-lives of both β-catenin and β-catenin pS552 , respectively, and FBXW2 promotes β-catenin polyubiquitylation via K48 linkage for degradation (Fig.  xref ); (4) EGF-activated AKT1 is responsible for β-catenin phosphorylation on Ser552, which facilitates its FBXW2 binding for degradation."
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"Expression of wild-type (wt) Cbp remarkably suppressed EGF-induced activation of Src, ERK1/2, and Akt-1 enzymes, and NIH3T3 cell transformation, as well as colony formation of a breast cancer cell line (MDA-MB-468) in soft agar."
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"In summary, these studies indicate that EGF signaling through EGFR activates PKBalpha and AKT as a principal target, and blocking this pathway with the EGFR specific tyrosine kinase inhibitor, Iressa, results in programmed cell death."
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"No induction of proliferation and survival was observed after EGF stimulation in Akt1 and Akt3 knockdown cells."
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"Mechanistically, EGF-induced activation of both AKT and RAC via PI3K was attenuated in cells expressing RBD-mutant p110α compared to those expressing WT p110α."
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"EGF stimulation induces activation of Akt-1 and ERK1/2 MAP kinase in corneal keratocytes."
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