IndraLab

Statements

MAP3K5 bound to TXN2 inhibits MAP3K5. 3 / 3
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"Trx2, like Trx1 XREF_BIBR, directly binds to ASK1, and forms a complex with ASK1 in mitochondria, inhibiting ASK1 activity XREF_BIBR."
19150880
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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [XREF_BIBR - XREF_BIBR]."
21945521
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"Since Trx2 bind to Apoptosis signal regulating kinase 1 (Ask1), a major mitogen activated protein kinase kinase kinase (MAPKKK) and inhibits Ask1 phosphorylation and activation, increased binding of Txnip to Trx2 reduces the interaction between Trx2 and Ask1 and induces Ask1 activation for apoptosis."
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