IndraLab

Statements

SGK1 activates KCNQ4. 3 / 4
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"SGK1 activates a wide variety of ion channels (e.g., ENaC, SCN5A, TRPV4-6, ROMK, Kv1.3, Kv1.5, Kv4.3, KCNE1 and KCNQ1, KCNQ4, ASIC1, GluR6, ClCKa and barttin, ClC2, CFTR, and Orai and STIM), which participate in the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation, and apoptosis."
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"Similarly, substitution of the putative phosphorylation site S444 in the K + channel KCNQ4 with Ala or Asp abolished Sgk1 modulation of KCNQ4."
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"Coexpression of wild type SGK1 but not coexpression of the inactive mutant (K127N) SGK1 significantly increased current amplitudes (by 67%) and significantly increased the resting potential of KCNQ4 expressing oocytes."
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