IndraLab

Statements

MYC increases the amount of CDKN2A. 14 / 17
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"Under physiologic conditions, c-MYC activation has been observed to induce the expression of p14ARF, which in turn inhibits MDM2 (103, 104)."
36439412
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"studies showing that the ARF gene encoded by the tumor-suppressive gene locus, INK4A, is induced after expression of c-MYC or other mitogenic transcription factors, like E2F [33]. The authors suggest that activation of cell cycle deregulating genes is translated into activation of the ARF gene, which encodes a p53-stabilizing protein [34]. Consistent with this model, fibroblasts from ARF-/- mice are largely refractory to c-MYC-induced apoptosis"
12769686
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"Oncogenic c-Myc can indirectly induce the expression of the tumor suppressor ARF, which leads to apoptosis through the stabilization of p53, but both c-Myc and ARF have apoptotic activities that are independent of p53."
21187408
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"These findings imply that let-7g might function as an inhibitor of HCC cell proliferation through direct repression of c-Myc, which may lead to re-expression of the tumor suppressor p16INK4A [XREF_BIBR]."
24690114
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"Further, reduced CMYC activity also leads to increased expression of p16 ( Guney et al., 2006 )."
25256683
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"We have shown that the cyclin dependent kinase Cdk2, although redundant for cell cycle progression, has a unique role in suppressing a Myc induced senescence program : Myc activation elicited expression of p16 (INK4a) and p21 (Cip1), and caused senescence in cells lacking Cdk2, but not in Cdk2-proficient cells."
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"For example, MYC induces the expression of the tumor suppressor ARF."
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"For example, while Myc binds to E-boxes of the p16 promoter and up-regulates p16 transcription, it has also been demonstrated that Myc can activate Bmi1, a potent repressor of the entire INK4b/ARF/INK4a locus."
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"In these cell types, Myc induces the expression of p19 Arf, which, by inactivating Mdm2, helps to enhance p53 dependent apoptosis (Zindy et al., 1998)."
12718877
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"In total, the high expression levels of CDKN1A and/or CDKN2A were associated with the low proliferation potentials of MKCLs and may be stimulated by the p53 and MYC pathways, respectively."
34861163
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"Myc has been shown to be suppressed by p53 through several different mechanisms, which include not only direct transcriptional repression but also the induction of miR‐145 and the lncRNA MILIP by p53.32, 33, 34, 35 On the other hand, Myc induces the mRNA expression of the alternative reading frame of p16 (ARF), which in turn activates p53.36 Myc has been demonstrated to confer a cancer stem cell–like phenotype to human HCC cell lines when the function of p53 is disrupted."
34051011
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"Treatment by chemotherapeutic agents like cisplatin has increased the c-Myc level which induces p14 ARF expression that in turn stabilizes P53 by binding and inhibiting Mdm2."
34995929
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"In addition, both c-Myc and E2F-1 induce Arf expression."
28085118
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"For example, physiologic thresholds of Myc and Ras signaling do not activate Arf gene expression, but overexpression of Myc and oncogenic Ras induces Arf."
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