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CDK4 phosphorylates RB1 on S780. 29 / 30
1 1 4 | 7 15 1
sparser
"We found that phorbol ester induces unusually early expression of cyclin D2 in B-1 but not B-2 cells, that this early-expressed cyclin D2 associates with Cdk4, and that this correlates with assembly of active kinase complexes and phosphorylation of Rb at the Cdk4 phosphoacceptor Ser 780 site."
10359571
hprd
No evidence text available
11254678
biopax:phosphositeplus
No evidence text available
sparser
"Conversely, during cell cycle progression, retinoblastoma protein (pRB) is sequentially phosphorylated by CYCLIN-CDK complexes, and CYCLIN D1-CDK4 specifically phosphorylates pRB on the Ser780 residue, leading to its inactivation and the release of E2F. xref In accordance with our transcriptomic data showing that both CCND1 and CDK4 gene expression were downregulated upon TYRO3 depletion (supplementary table  xref ), we observed lower levels of pRB phosphorylation at Ser780 in the three cell lines studied after TYRO3 knockdown, which may, therefore, lead to pRB activation and E2F inactivation, as suggested by IPA analysis of our transcriptomic data (Fig.  xref , lower panel)."
30765874
reach
"We conclude that a genetic background deprived of decorin favors cell cycle progression of HCC by repressing AP4, inducing p21 Waf1 and Cip1, and enhancing phosphorylation of P-Rb at Ser780 by CDK4 and CyclinD complex."
24361483
hprd
No evidence text available
19651622
reach
"The resulting loss of CDK4 function prevented downstream Rb phosphorylation at S780 and S807/811, leading to cell cycle arrest by failure at the S-phase checkpoint."
36484997
reach
"PRb is also phosphorylated at S780 by the cyclin D1 and cdk4 complex but not by the cyclin E and cdk2 complex."
27862183
sparser
"It is clear that CDK4 plays a critical role in the G1-S transition of the cell cycle by phosphorylating the retinoblastoma protein (pRb) and Ser-780 residue on Rb is specifically phosphorylated by CDK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12657252
reach
"Masatoshi et al. demonstrated that cyclin D and CDK4 complex is able to phosphorylate Rb at S780 in vivo and in vitro [XREF_BIBR]."
22263797
sparser
"CDK4 phosphorylates Rb at serine 780, allowing for hyperphosphorylation of Rb."
31727874
sparser
"Phosphorylation of pRb by Cdk4-cyclin D at specific site Ser780 inactivates pRb and leads to release of E2F proteins from the inhibitory pRb-E2F-complex [ xref ]."
19551155
hprd
No evidence text available
9003781
reach
"Cdk4 and Cdk6 can phosphorylate Rb at multiple sites including Ser 780, Ser 795 and Ser 807 [28]."
21705135
rlimsp
"Cdk4 specific phosphorylation of pRb on Ser780 and were normalized to total amount of pRb, β-actin served as internal control."
19551155
signor
"Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression."
23336272
sparser
"Cdk4 specific phosphorylation of pRb on Ser780 and were normalized to total amount of pRb, β -actin served as internal control."
19551155
reach
"The active cyclin D1 and CDK4 complex phosphorylates the Rb protein at Ser780, which results in the release of the E2F transcription factor from the Rb and E2F complex."
30519351
sparser
"Rb is phosphorylated on Ser 780 by cyclin D-CDK4 in early G 1 and on Ser 807/811 in late G 1 ( xref )."
18981099
sparser
"Both agents decreased Rb phosphorylation at the S780 CDK4 site ( xref ), while treatment with GSK2334470 alone or in combination with ribociclib decreased T308 P-AKT ( xref )."
28249908
sparser
"Ser780 on RB is specifically phosphorylated by CDK4 and not CDK2 and it is a robust marker of mitosis."
34815359
sparser
"Masatoshi et al. demonstrated that cyclin D-CDK4 complex is able to phosphorylate Rb at S780 in vivo and in vitro [ xref ]."
22263797
sparser
"While Cdk4-cyclin D efficiently and specifically phosphorylates pRb on Ser780 and Ser795, Cdk2-cyclin A/E does not."
19551155
sparser
"With CCND1 stimulation and CDKN2A inhibition, CDK4 phosphorylates the tumor suppressor retinoblastoma protein (RB) at serine780 and serine795 [ xref ], allowing pRB to activate the transcriptional factor E2F [ xref ]."
27708221
sparser
"The active cyclin D1-CDK4 complex phosphorylates the Rb protein at Ser780, which results in the release of the E2F transcription factor from the Rb-E2F complex."
30519351
sparser
"Thus, the dual role of Rb in regulating cell proliferation and differentiation is mediated by its phosphorylation status. xref Both cyclin D1-CDK4 and cyclin E-CDK2 phosphorylate Rb during the G1/S cell cycle progression, and cyclin D1-CDK4 specifically phosphorylates Rb at Serine 780 in vitro in human fibroblasts. xref We previously reported that sepsis inhibits cyclin-dependent kinase inhibitor p21 expression due to increases in the NFI-A protein. xref P21 inhibits the cyclin D1-CDK4 protein complex, which facilitates cell cycle arrest and promotes cell differentiation. xref , xref In this study, knockdown of cyclin D1 or CDK4 in sepsis Gr1 + CD11b + cells inhibited Rb phosphorylation at Serine 780 ( xref ), Rb knockdown displaced C/EBPβ from the miR promoters and simultaneously induced C/EBPα binding ( xref ) and abolished the miR promoter-driven reporter gene expression ( xref )."
27430527
hprd
No evidence text available
16326706
reach
"PRb is also phosphorylated at S780 by the cyclin D1 and cdk4 complex but not by the cyclin E and cdk2 complex (Futatsugi et al., 2012; Kitagawa et al., 1996)."
27862183
sparser
"It is well-established that pRb S780 phosphorylation by cyclin D-CDK4 is required for cells to progress through the G1/S checkpoint as this phosphorylation inactivates pRb, freeing E2F transcription factors to induce expression of genes needed to enter S phase ( xref , xref )."
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