IndraLab

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Modified MYC increases the amount of CDKN2A. 4 / 4
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"For instance, in the Emu-myc murine model of lymphoma, sustained over-expression of Myc signaling induces p19 Arf expression, resulting in apoptosis through the inhibition of Mdm2 and stabilization of the p53 tumor suppressor protein."
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"Myc overexpression induces p53 dependent apoptosis in part by inducing expression of the Mdm2-antagonist Arf and in part by promoting a DNA-damage response (DDR)."
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"Subsequent upregulation of the Epstein-Barr virus nuclear antigen 3C (EBNA3C) results in reduced c-Myc expression, attenuated DDR/R activity, and repressed p16 INK4A and p14 ARF expression, favoring t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A previous study showed that c-Myc overexpression not only induced p14ARF transcription but also stabilized p14ARF by inhibiting the ubiquitin ligase activity of ULF in normal fibroblast cells."
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