IndraLab

Statements

PKC phosphorylates KCNQ2. 16 / 16
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"In response to muscarinic agonists, PKC phosphorylates the KCNQ2 subunit and inhibits potassium current through the M channel, an important step in regulating neuronal excitability."
21495849
sparser
"PKC phosphorylation of the KCNQ2 channel subunit induces dissociation of calmodulin from the M-channel complex."
22643219
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"Recently, phosphorylation of KCNQ2 by protein kinase C (PKC) has been shown to dissociate CaM from KCNQ2 channels, leading to a reduced affinity to PIP 2 and suppression of M-current XREF_BIBR."
25077630
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"The in vitro kinase assay showed that KCNQ2 subunits of M channel can be phosphorylated by PKC."
20123983
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"Recent work indicates that protein kinase C (PKC) phosphorylation of the KCNQ2 subunit reduces the affinity for its PIP 2 binding and activities."
27466704
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"PKC phosphorylation of the KCNQ2 channel subunit induces dissociation of calmodulin from the M and channel complex."
22643219
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"This maintains PKC where it can optimally respond to activating signals from the m1 receptor and preferentially phosphorylate the KCNQ2 subunit."
20188672
sparser
"Previous work showed AKAP79 to co-precipitate with KCNQ2 channels (Cooper et al., 2000), and to facilitate PKC phosphorylation of KCNQ2 channels (Hoshi et al., 2003)."
21562284
sparser
"Muscarinic agonists such as acetylcholine mobilize an anchored pool of PKC that phosphorylates the KCNQ2 subunit of the M channel on Ser 541 to decrease potassium permeability ( xref )."
20188672
sparser
"AKAP79-bound CKAR should be a good proxy for PKC phosphorylation of AKAP79-bound KCNQ2."
23630338
sparser
"In neurons muscarinic agonists mobilize an AKAP79-anchored pool of PKC that phosphorylates the KCNQ2 subunit of the M channel."
20188672
reach
"Recent work indicates that protein kinase C (PKC) phosphorylation of the KCNQ2 subunit reduces the affinity for its PIP 2 binding and activities."
27466704
sparser
"In response to muscarinic agonists, PKC phosphorylates the KCNQ2 subunit and inhibits potassium current through the M channel, an important step in regulating neuronal excitability."
21495849
reach
"Previous work showed AKAP79 to co-precipitate with KCNQ2 channels (Cooper et al., 2000), and to facilitate PKC phosphorylation of KCNQ2 channels (Hoshi et al., 2003)."
21562284
sparser
"Activated PKC phosphorylates the C-terminus in the calmodulin (CaM) binding site of the Kv7.2 subunit assisted by A-kinase-anchoring protein AKAP79/150."
36002781
sparser
"Recently, phosphorylation of KCNQ2 by protein kinase C (PKC) has been shown to dissociate CaM from KCNQ2 channels, leading to a reduced affinity to PIP 2 and suppression of M-current xref ."
25077630