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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active CHEK2 phosphorylates TP53 on S20. 4 / 4

2 2 |

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bel

"12111733;10801407;15489221;15254178"

15212693

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"The CHK2 phosphorylates p53 at S20 and in turn activates it."

10673501

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"Two peptides derived from the DNA-binding domain of p53 bind to CHK2 and stimulate phosphorylation of full-length p53 at Thr 18 and Ser 20, thus identifying CHK2-docking sites."

12897801

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bel

"ATM is one of the major kinases that phosphorylate p53 at Ser15 after IR and that ATM also phosphorylates and activates Chk2 after IR, which then phosphorylates p53 at Ser20"

17967874

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...