IndraLab

Statements

reach
"The human POH1 gene encodes for a protein with a high degree of sequence similarity with fission yeast Pad1 (Fig. 2), is a fully functional homologue of Pad1 and induces by overexpression the same phenotype of pleiotropic drug resistance in S. pombe.To assess whether POH1 could be involved in resistance to cytotoxic insults and in particular to anticancer agents in mammalian cells, experiments of POH1 overexpression by transfection in mammalian cells were performed."
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reach
"Previous research demonstrated that deubiquitination enzyme genes play a role in developing drug resistance in malignant tumors and that interference with PSMD14 or PSMD14 inhibitors can reverse drug resistance in malignant tumors."
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