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CALM binds CACNA1C. 19 / 24
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"At high [Ca ], 2 molecules of Ca /CaM bind to Cav1.2 channels [217]."
37047381
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"In addition, we have demonstrated that CaM binding to the Cav1.2 channel also regulates the basal channel activity [ 17–19 ]."
30926461
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"Therefore, CaM-bound Cav1.2 channels at the resting condition (i.e., [CaM] = 200 nM, considered a high [CaM] in Z-line area [45]) and [Ca ] = 100 nM) represent approximately 10% of the total number of channels in the cell-free patches [51]."
37047381
sparser
"Taken together, it is reasonable to hypothesize that at ≈ free to low Ca 2+ conditions, binding of CaM to Cav1.2 with its N-lobe may be the dominant form to reprime channel activity."
25268113
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"Taken together, it is reasonable to hypothesize that at ≈ free to low Ca 2+ conditions, binding of CaM to Cav1.2 with its N-lobe may be the dominant form to reprime channel activity.It has been sugges[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25268113
sparser
"Based on the results, we propose a hypothesis by which interaction of the proximal and distal C-terminus modulates the dynamic interaction of CaM with Cav1.2 channels, which is involved in regulation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28391995
sparser
"We engineered CaV1.2-CaM fused channel using several lengths of glycine linkers (Gly2 to Gly12)."
26054929
sparser
"Mutations of the CaM-binding domain in the carboxy-terminal tail of the Cav1.2 channel α1C subunit disrupted binding of CaM to the channel and resulted in a loss of the regulatory effect of CaM [ xref , xref ]."
37047381
sparser
"In this line, it has been shown that calmodulin is tightly bound to the C terminus of Cav1.2 channels and serves as Ca 2+ sensor for CDI ( Erickson et al., 2003; Peterson et al., 1999; Zuhlke et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27889432
sparser
"Although CaM binds to the N-terminus of Cav1.2, a mutation in NSCaTE of Cav1.2 (Trp82, Ile86, and Rrg90 to TripleA) abolishing the binding of CaM only slightly weakened the CDI [ xref ]."
37047381
sparser
"Although the sequence between the EF-hand domain to preIQ ( 1555 QPPLG-RTALR 1601 , rabbit Cav1.2) shows high homology between Cav1.2 and Cav1.3, CaM binding to this region of Cav1.2 has yet to be verified."
37047381
sparser
"When the level of intracellular Ca 2+ increases in the microdomain of Cav1.2, Ca 2+ -bound calmodulin interacts with Cav1.2 and inactivates the channel [ xref ]."
33511453
sparser
"Notably, half-calcified CaM (Ca 2+ -bound only to C-lobe) bound to Cav1.2 channels with the C-lobe only (while the N-lobe is free) under resting conditions [see below ( xref )] [ xref ]."
37047381
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"Furthermore, co-crystallographic studies and even NMR structures of calmodulin bound to Cav1.2 and Cav2.1 have been reported [168,169,170,171,172,173,174]."
35682837
sparser
"Since the B max of IQ is larger than that of PreIQ, it can be inferred that at high [Ca 2+ ] and CS L concentrations, the two binding sites, IQ and PreIQ, might both be occupied by CS L . The Cav1.2 i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24462690
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"Future NMR studies are needed to determine the NMR structure of CaM/GluN1 C0 and test whether it is similar to the collapsed structure of CaM bound to CaV1.2 IQ (Fig. 4B)."
36739573
sparser
"CaM can also bind to the N-terminus of Cav1.2 and to the I–II intracellular linker [101,102] ."
19660468
sparser
"In contrast to CaV1.2-CaM, only one interaction is found between residues 120–149 in RyR2-CaM."
38870543
sparser
"Ca 2+ -CaM and CaV1.2 interaction is a dual-direction regulation on L-type calcium channel, including Ca 2+ -dependent facilitation (CDF) and Ca 2+ -dependent inactivation (CDI)."
26544729