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EGF phosphorylates GSK3B. 27 / 27
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"To verify whether Akt pathway was involved in hCSC proliferation, we examined the activation of Akt in hCSCs and found that EGF and bFGF treatment of hCSCs caused a rapid activation of Akt and also au[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, EGF significantly increased GSK-3β phosphorylation between 30–120 min (data not shown), with the most pronounced effect at 60 min, which was significantly reduced by BUD, but not FP, while total GSK-3β levels were not affected by BUD or FP (Fig.  xref )."
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"Lee et al. have reported that the chronic treatment of EGF in cervical cancer cells increased phosphorylation of GSK-3beta, a regulator of Snail [XREF_BIBR], inducing EMT [XREF_BIBR]."
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"siRNA-mediated knockdown of APPL1 in swCLCb H1299 cells reversed the EGF-dependent increase in Akt and GSK3β phosphorylation to levels similar to those in control siRNA-treated H1299 cells ( xref , xref )."
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"While BUD attenuated the EGF-induced phosphorylation of EGFR and its downstream target GSK-3β, FP was not able to do so."
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"Moreover, expression of NOTCH1-IC remarkably decreased EGF induced stimulation of GSK-3beta phosphorylation by ILK1."
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"Consistent with the known role of PDK1, IGF-1 and epidermal growth factor (EGF) -induced phosphorylation of AKT and GSK3β was also completely abolished in PDK1 deficient keratinocytes ( xref )."
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"Since ErbB2-4 receptor phosphorylation is required for substrate interaction and activation through tyrosine phosphorylation [XREF_BIBR, XREF_BIBR], a reduction in ErbB receptor activation also resulted in a corresponding decrease in EGF dependent phosphorylation (activation) of Akt, NFkappaB, and GSK-3beta."
22140606
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"Its increased expression correlates with prostate cancer progression to castration-resistant disease [ xref ] and it is essential for EGF-promoted cell migration and invasion, as well as for EMT markers expression [ xref ], AKT and GSK3β phosphorylation induced by EGF, and consequently for β-catenin stabilization [ xref ]."
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"To do so, we measured EGF-stimulated GSK-3β phosphorylation in the presence or absence of a well-established PI3K pathway inhibitor, Ly294002."
25622907
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"Since ErbB2-4 receptor phosphorylation is required for substrate interaction and activation through tyrosine phosphorylation [ xref , xref ], a reduction in ErbB receptor activation also resulted in a corresponding decrease in EGF-dependent phosphorylation (activation) of Akt, NFκB, and GSK-3β."
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"Down-regulation of endogenous XB130 with small interfering RNA (siRNA) reduced c-Src activity, IL-8 production, epidermal growth factor (EGF)-induced phosphorylation of Akt and GSK3β in human lung cancer A549 cells [ xref ]."
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"Indeed, EGF significantly increased GSK-3beta phosphorylation between 30-120min (data not shown), with the most pronounced effect at 60min, which was significantly reduced by BUD, but not FP, while total GSK-3beta levels were not affected by BUD or FP."
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"Phospho specific western blot analysis indicated that Iturin A caused sharp down regulation of EGF induced phosphorylation of Akt (Ser473 and Thr308) and its downstream proteins GSK3β and FoxO3a in treated groups without altering total proteins in both cell lines ( xref )."
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"The EGF-induced phosphorylation of Akt and GSK-3β were also significantly enhanced when the cells were pretreated with 3 μM Y27632 for 1 h, although the increases were less dramatic than those for either MEK1/2 or p44/p42 MAP kinase."
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"Down-regulation of endogenous XB130 with siRNA reduced c-Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells."
17412687
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"Its increased expression correlates with prostate cancer progression to castration resistant disease [XREF_BIBR] and it is essential for EGF promoted cell migration and invasion, as well as for EMT markers expression [XREF_BIBR], AKT and GSK3beta phosphorylation induced by EGF, and consequently for beta-catenin stabilization [XREF_BIBR]."
28430640
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"We next examined the effects of Y27632 on the EGF-induced phosphorylation of Akt and GSK-3β in Panc1 cells, since GSK-3β is a critical downstream element of the PI3K/Akt pathway in EGFR signaling [ xref ]."
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"In RKTG-null mouse embryonic fibroblasts, lypophosphatidic acid (LPA), but not EGF (epidermal growth factor), could stimulate hyperphosphorylation of AKT and GSK3beta, accompanied by increases in phosphorylation of p53 at Ser15 and accumulation of p53, as well as its target genes p21 and p16."
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"Moreover, expression of NOTCH1-IC remarkably decreased EGF-induced stimulation of GSK-3beta phosphorylation by ILK1 (B)."
26547035
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"Mechanistically, we found that Hsp27 is required for EGF-induced AKT and GSK3β phosphorylation and β-catenin nuclear translocation."
25130271
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"EGF induced the phosphorylation of the phosphatidylinositol 3-kinase (PI3-K)-dependent proteins, Akt and GSK-3beta as well as both p42/44 MAPK and p38 mitogen-activated protein kinases (MAPK)."
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"Down-regulation of endogenous XB130 with siRNA reduced c-Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells."
17412687
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"Similarly, we found that EGF and Insulin (GF) treatment of primary MECs and LECs, as well as HME50 cells, increased the phosphorylation of Akt and GSK-3beta (XREF_FIG, XREF_SUPPLEMENTARY))."
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"Mechanistically, we found that Hsp27 is required for EGF induced AKT and GSK3beta phosphorylation and beta-catenin nuclear translocation."
25130271
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"siRNA mediated knockdown of APPL1 in swCLCb H1299 cells reversed the EGF dependent increase in Akt and GSK3beta phosphorylation to levels similar to those in control siRNA treated H1299 cells (XREF_FIG, XREF_SUPPLEMENTARY)."
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"The induction of AKT1 and GSK-3β phosphorylation by EGF can be suppressed by the inhibition of Ca 2+ /CaM signaling [ xref ]."
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