IndraLab

Statements

CTNNB1 binds FHL2 and LEF1. 10 / 10
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"Released EpICD associates with FHL2, β-catenin and Lef-1 to form a nuclear complex and triggers oncogenic signaling."
27176150
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"Furthermore, β-catenin is able to bind simultaneously to FHL2 and the transcription factor LEF-1, forming a ternary protein complex."
12370240
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"Consistent with this prediction, we could show the formation of an FHL2–β-catenin–LEF-1 ternary protein complex in a GST pull-down assay with bacterially expressed GST–FHL2 and in vitro–translated myc–β-catenin and HA–LEF-1 ( xref , lane 8)."
12370240
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"Maetzel et al ( xref ) revealed that knockdown of EpCAM in FaDu cells results in decreased proliferation, and they concluded that the proliferative action of EpCAM was attributed to the ability of EpICD to form a transcription activator complex with four and a half LIM domains 2, β-Catenin and lymphoid enhancer binding factor 1 (LEF1) ( xref )."
30015855
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"Following RIP, the EpICD fragment is translocated from the cytoplasm into the nucleus and form complex with FHL2, beta-catenin, and Lef-1, stimulating the expression of c-Myc and cyclin A/E genes [ xref ]."
32046162
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"The released EpICD forms nuclear protein complex by interacting with the FHL2, β-catenin and Lef1 mediates gene transcriptions and aids in cell proliferation."
26176230
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"Membrane EpCAM is cleaved in cancers and its intracellular domain (EpICD) is transported into the nucleus and binds β-catenin, FHL2, and LEF1."
34209658
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"By inhibiting the cleavage of EpCAM, EpAb2-6 prohibits tumor growth by preventing the translocation of EpICD into the nucleus (Fig. xref ), thus preventing the binding of EpICD to a multiprotein complex consisting of FHL2, β-catenin, and Lef-1, and thereby blocking both the down-regulation of p53 and p21, and the activation of EMT and iPS genes."
26317650
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"EpICD binds to DNA in a complex with the scaffolding protein FHL2, β-catenin, and Lef-1, and regulates cell proliferation ( xref )."
21464043
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"Released EpICD forms a nuclear complex with FHL2, Lef-1 and β-catenin, activating the downstream signal transduction pathway []."
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