IndraLab

Statements

SGCG activates USP18. 5 / 5
| 5
reach
"Firstly, like ISG15 itself, the predominant ISG15 conjugation and deconjugation enzymes UbE1L, UbcH8/UbcM8, HERC5/HERC6, and UBP43/USP18 are all induced by type I IFN stimulation."
24095857
reach
"Further temporal regulation of the ISG15 system by expression of the type I IFN-induced cellular deconjugase (human Usp18/mouse Ubp43), as well the role of free intracellular ISG15 in downregulating signaling at the type I IFN receptor in human cells, remains to be explored.We have shown that ISG15 is secreted from both lymphocytes and epithelial cells, suggesting that the ISG15 secretion mechanism is operational in a wide range of cell types."
| PMC
reach
"b | Intracellular functions: Ubl carboxy-terminal hydrolase 18 (USP18) and S-phase kinase-associated protein 2 (SKP2): USP18, which is induced by type I interferons, mediates the negative feedback regulation of interferon signalling independent of its deISGylase activity."
29769653
reach
"19 The Usp18 gene is rapidly and strongly upregulated after viral infection or by type I and type III IFNs, 1, 6, 13, 19, 20 lipopolysaccharide (LPS), 21, 22 tumor necrosis factor alpha (TNF-α), 22 or genotoxic stress 13, 23 (Figure 2a )."
27809302
reach
"The cloning of USP18 was also independently reported by 3 other groups in various species, and all confirmed the induction of USP18 by Type 1 IFN (Zhang and others 1999; Li and others 2000; Kang and others 2001) , consistent with the finding of highly conserved ISREs in the UBP43 promoter (Malakhova and others 2002) ."
21190487