IndraLab

Statements

Modified RAS increases the amount of TP53. 4 / 4
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"It has been shown that expression of Ras or activation of the MAPK pathway increases wild-type p53 levels and can cause permanent growth arrest."
11781291
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"RAS can activate mRNA transcription and translation of Mdm2 and p53, as well as induce ARF, a tumor-suppressor protein that binds MDM2 and blocks MDM2 mediated p53 degradation in a cell-type dependent manner."
20417299
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"Conversely, continuous overexpression of oncogenic Ras and its various effectors can lead to irreversible cell cycle arrest by upregulating the levels of p16 Ink4a, p19 Arf, and p53."
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"We found that over-expression of ras in normal haemocytes did not lead to a higher expression of p53 or Mdm as found in vertebrates."
20417299