IndraLab

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EGFR binds GRB2 and SH2 domain. 4 / 4
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"Grb2 binds to the tyrosine phosphorylated cytoplasmic tail of the activated epidermal growth factor receptor through its SH2 domain and thereby relocates Sos from the cytoplasm to the plasma membrane [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"GRB2 binds the EGFR and contains one SH2 domain and two SH3 domains, which are crucial for IL3 signaling in hematopoietic stem and progenitor cell."
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"These discoveries were extended to mammalian systems, where it was shown that the Grb2 SH2 domain could inducibly bind the tyrosine phosphorylated epidermal growth factor receptor (EGFR) while bound constitutively to son of sevenless (SOS), a guanine nucleotide exchange factor for Ras."
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"The SH2 domain of GRB2 binds to the tyrosine auto- phosphorylation sites of activated EGF receptor [14], suggesting that the interaction of Sem-5 with Let-23 is direct."