IndraLab

Statements

USP1 activates CHEK1. 5 / 6
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"Finally, to ascertain if elements other than mono-Ub-FANCD2 participate in USP1 mediated CHK1 downregulation, we depleted USP1 in FA-C, FA-G and FA-D2 fibroblasts."
21389083
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"Two E3 ligase complexes, CUL4A and DDB1 and CUL1 and FBXO6, have shown to be responsible for Chk1 polyubiquitination and degradation; whereas deubiquitinases (DUB), USP1 and USP7, have been reported to promote Chk1 stabilization."
28180282
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"It has been previously reported that deubiquitinase USP1 maintains both total and phosphorylated Chk1 level and that USP1 deletion promotes degradation of activated Chk1 in a DDB1 dependent manner."
28180282
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"USP1 limits DDB1 dependent degradation of CHK1."
21389083
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"USP1 enhanced protein stability of the ID1 and CHEK1, important regulators of DNA damage response and stem cell maintenance (Lee et al., 2016)."
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