IndraLab

Statements

DNAJB1 inhibits ATXN3. 6 / 7
| 6
reach
"Over-expression of the Drosophila DNAJB1 homolog, dHDJ1, suppressed polyQ Htt- and ATXN3 dependent toxicity [XREF_BIBR, XREF_BIBR], and the effect of dHDJ1 on ATXN3 mediated toxicity was enhanced by over-expression with wildtype Hsp70 but inhibited by co-expression with a dominant negative mutant of Hsp70."
31552448
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"An overexpression of HSP40 and HDJ -2 suppressed ataxin-3 and ataxin-1 aggregation in vitro [XREF_BIBR, XREF_BIBR], but not in huntingtin exon 1 overexpressing cell lines [XREF_BIBR]."
25309920
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"DNAJA1 effectively degrades huntington aggregates; DNAJB1 can degrade protein aggregates ataxin-3; DNAJB2 can inhibit the formation of huntington aggregates; DNAJB6 can inhibit the aggregation of Aβ 42 and α-synuclein; DNAJC5 can promote the release of TDP-43, τ protein, and α-synuclein into the extracellular space."
36581576
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"In support of this, it has been shown that overexpression of DNAJB1 restores the cellular degradation capacity [23] and suppresses aggregation of polyQ expanded ATXN3 [24]."
30086154
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"DNAJB1 was identified to suppress aggregate formation of ATXN3, but aggregation of the S256A mutant of ATXN3 could not be prevented by DNAJB1, it is still unclear whether DNAJB1 has preferential affinity for phosphorylated ATXN3."
28386214
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"For example, HSP40 and HSP70 were reported to localize in the intranuclear aggregates formed by mutant ataxin-3 and that overexpression of HSP40 reduces aggregation of truncated and full-length Atx3 XREF_BIBR."
21625540