IndraLab

Statements

TBK1 inhibits CYLD. 2 / 2
| 2
reach
"Furthermore, the activation of TBK1 is also negatively regulated by the phosphatases PPM1A (protein phosphatase magnesium dependent 1A), PPM1B, and PP4, as well as the deubiquitinating enzymes CYLD (cylindromatosis) and USP2b (ubiquitin specific protease 2b)."
30101190
reach
"Because it was technically challenging to knockdown all four kinases of the IKK family simultaneously in a stable format, we resorted to using a dominant negative approach overexpressing a kinase-inactive TBK1, which could potentially block all the CYLD kinases."
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