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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TBK1 inhibits CYLD. 2 / 2

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"Furthermore, the activation of TBK1 is also negatively regulated by the phosphatases PPM1A (protein phosphatase magnesium dependent 1A), PPM1B, and PP4, as well as the deubiquitinating enzymes CYLD (cylindromatosis) and USP2b (ubiquitin specific protease 2b)."

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"Because it was technically challenging to knockdown all four kinases of the IKK family simultaneously in a stable format, we resorted to using a dominant negative approach overexpressing a kinase-inactive TBK1, which could potentially block all the CYLD kinases."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...