IndraLab

Statements

USP10 leads to the ubiquitination of CFTR. 2 / 2

| 2

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"siRNA mediated knockdown of USP10 increased the multi ubiquitination and lysosomal degradation of CFTR and decreased the endocytic recycling and the half-life of CFTR in the apical membrane, as well as CFTR mediated chloride secretion."

20215869

➶

reach

"Cif does this by stabilizing G3BP1 mediated inhibition of USP10, which then reduces USP10 mediated deubiquitination of CFTR and enhances degradation of CFTR in a lysosome [XREF_BIBR]."

23151130

INDRA sources:

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IndraLab

Statements

USP10 leads to the ubiquitination of CFTR. 2 / 2

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