IndraLab

Statements

USP1 decreases the amount of USP1. 5 / 6
| 5
reach
"A doxycycline induced USP1 shRNA suppressed USP1 expression and reduced ID1 and ID2 in the xenografts."
21925315
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"The important regulatory role of USP1 in DNA repair, supported by the finding that USP1 gene knockout in model systems leads to DNA damage hypersensitivity [XREF_BIBR - XREF_BIBR], together with the observation that USP1 is frequently overexpressed in tumors, suggests that USP1 could be a relevant target for cancer therapy, whose inhibition might contribute to overcome chemoresistance."
23937906
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"USP1 overexpression reversed the effects of NRF1 knockdown on USP1 and AURKA expression and on OS cells trends and in vivo tumor growth."
39915374
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"Similar to previous studies, we found that USP1 inhibition decreased USP1 protein levels (43)."
37478161
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"miR-375 overexpression down-regulated USP1 expression and negatively regulated USP1-mediated NPC cell migration, invasion, and apoptosis."
34626803