IndraLab

"Results form mass spectrometry , co-immunoprecipitation , and ubiquitination assays demonstrated that USP11 interacted with nuclear factor 90 ( NF90 ) and promoted its deubiquitination , thereby stabilizing it in HCC cells ."

"100 A recent study indicated that USP7 stabilizes the Hippo pathway by deubiquitinating the transcriptional coactivator Yorkie , promoting HCC growth.101 Further , USP7 participates in lipogenesis-associated HCC progression by promoting stabilization and transcription of zinc-finger protein 638.102 USP11 is upregulated in HCC and is correlated with shorter survival in HCC patients.103 ,104 USP11 promotes HCC cell survival , invasion , and metastatic potency in vitro and in vivo.103 ,104 Mechanistically , USP11 interacts with nuclear factor 90 ( NF90 ) and promotes its deubiquitination , thereby stabilizing it in HCC cells.103 Consistent with this , USP11 expression positively correlates with NF90 expression in human HCC tissues.103 Similar to USP11 , elevated USP13 in HCC patients is associated with a poor prognosis ."