IndraLab

Statements

reach
"In addition, CYLD modulates dendritic growth and postsynaptic differentiation in mouse hippocampal neurons [XREF_BIBR]."
33318303
reach
"The decreased JNK pathway activation in the H-CYLD WT cells appears as a plausible mechanism for CYLD induction of keratinocytes differentiation."
21900959
reach
"Furthermore, depletion of beta-TRCP induced CYLD accumulation and TRAF6 deubiquitination in osteoclast precursor cells, leading to suppression of RANKL induced osteoclast differentiation."
24961988
reach
"As a result, we have found that forced expression of wild-type CYLD (CYLD WT) both in HaCaT keratinocytes and in the skin equivalents enhances keratinocyte differentiation, while the inhibition of CYLD function by expression of a catalytically inactive form of CYLD impairs epidermal differentiation."
21900959
reach
"The diminished function of CYLD impairs the differentiation of keratinocytes in human HaCaT skin equivalents."
21900959
reach
"Our data demonstrate that alterations in CYLD expression in keratinocytes disrupt normal epidermal homeostasis : the forced expression of CYLD WT in human HaCaT keratinocytes and the skin equivalents enhance keratinocyte differentiation."
21900959
reach
"Increased CYLD expression enhances the differentiation of keratinocytes in human skin equivalents."
21900959
reach
"Importantly, we have discovered that CYLD WT also promotes the differentiation of A431 tumoral keratinocytes through inhibition of JNK activation."
21900959
reach
"We show that CYLD overexpression increases keratinocyte differentiation while CYLD loss of function impairs epidermal differentiation."
21900959
reach
"In addition to the skin appendages changes, the K5-CYLD C/S mice show epidermal alterations, mainly impaired keratinocyte differentiation, thus confirming in vivo the results that our group have previously described using a model of skin equivalents of human HaCaT keratinocytes [XREF_BIBR], in which we demonstrated that the overexpression of the wild-type CYLD (CYLD wt) promoted keratinocyte differentiation, whereas the expression of the mutant CYLD C/S prevented, through the activation of the JNK pathway, the epidermal differentiation [XREF_BIBR]."
30631004