IndraLab

Statements

USP7 increases the amount of SUV39H1. 3 / 3
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reach
"To investigate whether USP7 modulates SUV39H1 expression levels, we generated HCT116 p53 wt cells stably expressing doxycycline inducible USP7 shRNA."
26971997
reach
"Transient transfection of H1299 or HCT116 p53 -/- cells revealed that exogenous MDM2 expression led to downregulation of exogenous SUV39H1 protein levels (XREF_FIG; XREF_SUPPLEMENTARY), while USP7 co-transfection rescued SUV39H1 expression in a dose dependent manner (XREF_FIG)."
26971997
reach
"Our present studies establish that USP7 is enriched on p53 target promoters and modulates SUV39H1 and H3K9me3 levels in a MDM2 dependent manner."
26971997