IndraLab

Statements

USP7 increases the amount of SUV39H1. 6 / 6
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reach
"Transient transfection of H1299 or HCT116 p53 -/- cells revealed that exogenous MDM2 expression led to downregulation of exogenous SUV39H1 protein levels (XREF_FIG; XREF_SUPPLEMENTARY), while USP7 co-transfection rescued SUV39H1 expression in a dose dependent manner (XREF_FIG)."
26971997
reach
"Our present studies establish that USP7 is enriched on p53 target promoters and modulates SUV39H1 and H3K9me3 levels in a MDM2 dependent manner."
26971997
reach
"Our present studies establish that USP7 is enriched on p53 target promoters and modulates SUV39H1 and H3K9me3 levels in an MDM2 dependent manner."
26971997
reach
"Transient transfection of H1299 or HCT116 p53 -/- cells revealed that exogenous MDM2 expression led to downregulation of exogenous SUV39H1 protein levels, while USP7 co-transfection rescued SUV39H1 ex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26971997
reach
"To investigate whether USP7 modulates SUV39H1 expression levels, we generated HCT116 p53 wt cells stably expressing doxycycline inducible USP7 shRNA."
26971997
reach
"The present studies define a role of USP7 in the regulation of MDM2 mediated SUV39H1 degradation and maintenance of the H3K9me3 repressive chromatin conformation on p53 target promoters in unstressed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26971997