IndraLab

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"Negative regulators of linear ubiquitination-dependent NF-κB activation have recently been reported, including the FAM105B (otulin) and CYLD linear ubiquitin-specific deubiquitinases (DUBs) and A20, which specifically binds the linear ubiquitin moiety and edits Rip1 ubiquitination to inhibit its activation ( xref ; xref ; xref ; xref ; xref )."