IndraLab

Statements

TP53 binds MDM2 and RING. 6 / 6
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"The mRNA of p53 can interact with the RING domain of MDM2, which prevents the E3 ligase activity and furthermore stimulates translation of the p53 mRNA [ xref ]."
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"Lastly, although the RING domain of MDM2 does not bind to p53 directly, it possesses E3 ligase activity and is thus responsible for ubiquitinating p53 and marking it for degradation."
25808808
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"The p53 mRNA interacts with the C-terminal RING domain of MDM2 ( xref ) and as we did not expect MDM2 to have more than one RNA binding domain we were surprised to observe that deletion of the RING domain (MDM2-ΔRING) resulted in a constitutive non-regulated binding to the E2F1 mRNA (Figure xref and xref )."
32453417
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"Mdm2 associates with p53 polysomes via its RING domain and probably enhances translation."
26498036
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"For example, the RING domain of MDM2 can bind to p53 mRNA and promote its translation ( xref )."
27666947
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"Du et al. found that circFOXO3 acted as a protein scaffold recruiting both MDM2 and p53 to form MDM2-p53 complex via binding with the RING-finger domain of MDM2 and C-terminal regulatory domain of p53 respectively."
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