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MDM2 bound to it inhibits TP53. 2 / 2

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"While exogenous Arf can sequester MDM2 to nucleoli (XREF_FIG), subsequent studies indicate that nucleolar stress releases Arf to the nucleoplasm where it binds and blocks MDM2, XREF_BIBR, XREF_BIBR thus allowing p53 to accumulate and block cell cycle progression (XREF_FIG)."

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"p19 Arf accumulates in the nucleolus, where it binds NPM1 and Mdm2 to suppress tumor development by inhibiting ribosome biogenesis and initiating p53 dependent senescence and apoptosis, respectively."

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MDM2 bound to it inhibits TP53. 2 / 2

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