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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

MDM2 bound to it inhibits TP53. 2 / 2
| 2
reach
"p19 Arf accumulates in the nucleolus, where it binds NPM1 and Mdm2 to suppress tumor development by inhibiting ribosome biogenesis and initiating p53 dependent senescence and apoptosis, respectively."
reach
"While exogenous Arf can sequester MDM2 to nucleoli (XREF_FIG), subsequent studies indicate that nucleolar stress releases Arf to the nucleoplasm where it binds and blocks MDM2, XREF_BIBR, XREF_BIBR thus allowing p53 to accumulate and block cell cycle progression (XREF_FIG)."