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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to it inhibits TP53. 2 / 2

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"p19 Arf accumulates in the nucleolus, where it binds NPM1 and Mdm2 to suppress tumor development by inhibiting ribosome biogenesis and initiating p53 dependent senescence and apoptosis, respectively."

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"While exogenous Arf can sequester MDM2 to nucleoli (XREF_FIG), subsequent studies indicate that nucleolar stress releases Arf to the nucleoplasm where it binds and blocks MDM2, XREF_BIBR, XREF_BIBR thus allowing p53 to accumulate and block cell cycle progression (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...