IndraLab

Statements

USP7 activates FOXP3. 5 / 5
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"We now report that both Tip60 and Foxp3 proteins are subject to ubiquitination and proteasomal degradation, whereas the actions of a deubiquitinating (DUB) enzyme, ubiquitin specific protease, Usp7 (also known as HAUSP), counteract these events and promote Tip60 and Foxp3 stability and, consequently, Treg suppressive function."
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"Hence, Usp7 can promote assembly of higher order complexes of Foxp3, including formation of Foxp3 dimers that are essential for optimal Foxp3 binding to DNA in Treg cells, whereas Usp7i treatment can disrupt assembly of such complexes."
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"Indeed, USP7 decreased the rate of degradation of Foxp3 (XREF_SUPPLEMENTARY)."
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"The deubiquitinase USP7 is upregulated in Tregs and prolongs the half-life of FOXP3 protein by reducing its ubiquitin mediated degradation rate."
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"USP7 knockdown or inhibition by a DUB inhibitor reduces the level of Foxp3 protein and compromises the function of Treg cells 273."
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