IndraLab

Statements

SHC binds SOS1 and GRB2. 6 / 6
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"RTKs activates RAS in non-tumoral cells by recruiting the SHC-GRB2-SOS1 complex independently of SHP2 [72]."
34064232
sparser
"Ligation of the BCR with anti-IgM antibodies causes an elevation of Ras-GTP levels from about 15% to 25% and coincides with the formation of complexes containing phosphorylated Shc, Grb2 and Sos1 ."
12384139
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"Both the Shc-Grb2-Sos1 complex and TGF-beta-receptor-Strap complex were included, which function in the GPCR/RTK signaling pathway and the TGF-beta-receptor signaling pathway, respectively."
31671542
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"XREF_BIBR, XREF_BIBR, XREF_BIBR In normal cells, RTKs activates Ras by recruiting the SHC, GRB2, and SOS1 complex independent of SHP2."
32939510
sparser
"Together, these data suggest that the current model for regulation of p21ras, which proposes a stable association of Shc-grb2-Sos1 complexes at the plasma membrane, may be an oversimplification."
8063737
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"We also show that the Cbl and EGF receptor complex is predominantly associated with CrkII and is distinct to the Grb2, Shc, and Sos1 complex that associates with the EGF receptor."
9416834