IndraLab

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BAP15 inhibits UCHL5. 4 / 4
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"Taken together, these data reveal that the inhibition of UCHL5 by bAP15 stabilizes Smad2 and induces downregulation of TGF-β signaling."
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"In the present study, we revealed, for the first time, evidence of the clinical significance of cytoplasmic UCHL5 expression in ovarian cancer, and demonstrated that bAP15 significantly suppressed UCHL5 in TP53-mutant ovarian cancer cell lines in a dose-dependent manner through downregulation of the TGF-β/Smad signaling pathway (Figure 7)."
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"As shown in Figure 3, in line with our previous results in ovarian cancer cell lines, the addition of bAP15 inhibited UCHL5 and reduced cell invasiveness, as determined by Matrigel cell invasion experiments."
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"In contrast to 20S proteasome inhibitors, bAP15 blocks the deubiquitylating activity of both USP14 and UCHL5 to induce strong anti-tumor activity without affecting proteolytic activities of the 20S proteasome [25, 26, 28, 29]."
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