IndraLab

Statements

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"Interaction of CYLD with tubulin and MT. We have earlier shown that UV or TPA treatment of primary mouse keratinocytes triggers perinuclear accumulation of CYLD, which correlates with its ability to interact with its downstream targets."
19893491
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"These data suggest that TPA increases tumor promotion in Cyld -/- mice by enhancing tumor cell proliferation."
16713561
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"Importantly, TPA or UV-B failed to activate the Mut-CD1 promoter in Cyld +/+ as well as Cyld -/- keratinocytes, indicating that Cyld modulates TPA- or UV-B-mediated cyclin D1 promoter activation in an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16713561
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"As expected, TPA induced interaction of CYLD with Bcl-3, while this interaction (XREF_FIG), as well as perinuclear localization of CYLD (XREF_SUPPLEMENTARY), was prevented in the presence of nocodazole."
19893491
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"Importantly, nuclear accumulation of Bcl-3 was also significantly increased in DMBA and TPA induced Cyld -/- tumors when compared with tumors from control littermates."
16713561
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"This is supported by the finding that depletion of HDAC6 was not sufficient to induce the interaction of CYLD with Bcl-3, but TPA mediated activation of CYLD is additionally required."
19893491
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"TPA stimulated Cyld +/+ keratinocytes and EGFP-CYLD-expressing melanoma cells showed reduced levels of BrdU positive nuclei as an indication of delayed S-phase progression in the presence of activated CYLD (XREF_FIG)."
19893491
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"In addition, we found that TPA treatment of Cyld +/+ keratinocytes caused redistribution of CYLD and induced its accumulation in the perinuclear region, which has been previously shown to be critical in mediating the interaction with its downstream substrate Bcl-3."
19893491