IndraLab

Statements

PRDX5 deubiquitinates ZUP1. 2 / 2
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"PLP deubiquitinating (DUB) activity has been demonstrated in several CoV species, and acts directly and indirectly on several signal molecules in the IRF-3-dependent IFN induction pathway including retinoic acid inducible gene-I (RIG-I), tumor necrosis factor receptor-associated factor 3 (TRAF3), TANK-binding kinase 1 (TBK1) and STING [30, 31]."
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"One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN)."
20181693