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Mutated SCN1A inhibits NAV1. 1 / 1

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"In addition, the model experiment of gene knockout mice for simulating human channel diseases has verified that SCN1A mutation causes reduced expression level of sodium channel subtype Nav1.1, leading to decreased excitatory of inhibitory neurons, functional decline in inhibitory loop and increased neuronal excitability, which are necessary for the onset of epileptic seizures [XREF_BIBR]."

28474565

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Mutated SCN1A inhibits NAV1. 1 / 1

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