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"A recent study revealed that USP14 knockdown inhibited the migration of breast cancer cells by increasing the expression of vimentin and reducing the expression of E-cadherin, suggesting that USP14 might enhance the metastatic ability of breast cancer cells by initiating the epithelial-mesenchymal transition process.20 However, whether USP14 promotes ESCC metastasis through the same mechanism or other pathways remains unclear."