IndraLab

Statements

USP14 decreases the amount of CDH1. 3 / 3
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"USP14 overexpression elevated the profiles of Vimentin, Snail1, ZEB1, and Slug while repressing the E-cadherin level (compared with the vector group, Figure 2F)."
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"A recent study revealed that USP14 knockdown inhibited the migration of breast cancer cells by increasing the expression of vimentin and reducing the expression of E-cadherin, suggesting that USP14 might enhance the metastatic ability of breast cancer cells by initiating the epithelial-mesenchymal transition process.20 However, whether USP14 promotes ESCC metastasis through the same mechanism or other pathways remains unclear."
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"Furthermore, WB results revealed that USP14 knockdown enhanced E-cadherin levels while reducing Vimentin, Snail1, ZEB1, and Slug profiles (Figure 4F)."
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