IndraLab

Statements

USP15 inhibits proteolysis. 5 / 5
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reach
"Further investigation demonstrated the significance of Nef- and USP15 mediated viral and cellular protein degradation with respect to the regulation of the virus life cycle and HIV-1 and host cell competition that is essential for AIDS progression."
27460547
reach
"Further investigation demonstrated the significance of Nef- and USP15 mediated viral and cellular protein degradation with respect to the regulation of the virus life cycle and HIV-1 and host cell com[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27460547
reach
"To investigate Nef role in protein degradation, we seek to identify cellular proteins involved in the UPS mediated protein degradation through association with Nef and found ubiquitin specific protease 15 (USP15) which stabilizes proteins by deubiquitylation and by preventing autoubiquitylation of substrates."
27460547
reach
"We found that Nef binds to ubiquitin protein ligase E3A (UBE3A and E6AP) which induces protein degradation by attaching Ub to substrates, i.e. Nef associated with two functionally antagonistic proteins in the UPS mediated protein degradation processes, suggesting that UBE3A could be a major cellular component in regulating USP15 mediated viral protein degradation by interacting with Nef and USP15 simultaneously or independently."
27460547
reach
"To investigate Nef role in protein degradation, we seek to identify cellular proteins involved in the UPS mediated protein degradation through association with Nef and found ubiquitin specific proteas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27460547