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NFkappaB activates TNFAIP3. 29 / 29
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"TNFAIP3 (also known as A20) expression is up-regulated by NF-kB activation, as confirmed in our study, and it acts in a negative feedback loop to control NF-kB-dependent gene expression."
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"As A20 ZF4 proteins are recruited poorly to TNFR signaling complexes, the presence of normal NF-kappaB signaling in Tnfaip3 OTU and ZF4 cells also raises the interesting possibility that A20 OTU proteins may dimerize with A20 ZF4 proteins and recruit the latter to TNFR signaling complexes in Tnfaip3 OTU and ZF4 cells."
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"Additionally, TNIP1 has been proposed to inhibit NF-κB activation independently of TNFAIP3, possibly by competing with NF-κB mediator proteins for polyubiquitin [ xref ]."
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"Overexpression of A20 resulted in suppression of cytokine-triggered NF-kappaB activation and knockdown of A20 by RNA interference significantly attenuated induction of anergy by ER stress."
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"In addition , Kadiyala et al. reported that GR and NF-kappaB cooperatively bound to the enhancer of the A20 locus and induced A20 expression ( 35 ) ."
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"TCR specific signalling protein MALT1 (through the CARD11-BCL10-MALT1 complex) was recently reported to be required for optimal NF-κB activation through proteolysis of the NF-κB inhibitor TNFAIP3 [ xref , xref ]."
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"Furthermore, TNFAIP3 is activated by NF-κB in response to pro-inflammatory signals such as TNF-α and can inhibit inflammation and programmed cell death."
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"TNFAIP3 is rapidly induced by NF-kappaB and feeds back to deubiquitinate RIP within 30 minutes of stimulation and to stop NF-kappaB activation within 60 minutes of TNF treatment XREF_BIBR, XREF_BIBR."
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"Upon NF-κB activation of A20 and IκBα genes, P-TEFb is released, and DSIF accompanies the elongating Pol II."
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"43 We determined that Casp8 increased A20 expression by activating NF-kappaB and cleaving RIP1 ."
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"Mutations and copy number abnormalities of NF-kappaB genes occurred in 36 (36%) of 101 SMZLs and targeted both canonical (TNFAIP3 and IKBKB) and noncanonical (BIRC3, TRAF3, MAP3K14) NF-kappaB pathways."
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"A20 is regulated at the level of gene transcription 6, whereby NF-kappaB activation induces TNFAIP3 expression XREF_BIBR, XREF_BIBR forming a negative feedback loop, and the inhibitory activities of A20 enzymatic sites are enhanced by IKKB mediated serine phosphorylation at Ser381 XREF_BIBR, XREF_BIBR."
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"The observation that A20 OTU and A20 ZF4 proteins complement each other to normally regulate NF-kappaB signaling in Tnfaip3 OTU and ZF4 cells suggests that A20 OTU proteins rescue the aberrant RIP1 ubiquitination and defective homing of A20 ZF4 proteins observed in Tnfaip3 ZF4 and ZF4 cells."
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"A20 is a protein with dual enzymatic activity (DUB/E3 ligase) encoded by the NF-kB induced gene TNF alpha induced protein 3 (TNFAIP3). xref A20 stops NF-κB activation by (1) deubiquitinating RIPK-1 and (2) polyubiquitinating RIP-1 to target it for degradation (proteolysis)."
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"A co-occupied intronic TNFAIP3 regulatory element mediated cooperative enhancement of transcription by GR and NF-kappaB that required the presence of a functional GR binding site (GBS)."
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"Along with the activation of inflammation-related genes , NF-kappaB induces IkappaBs and A20 ."
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"XREF_BIBR, XREF_BIBR Both miR-125b 37 and TNFAIP3 38 are induced by NF-kappaB activity."
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"Thus, we suggest the ability of COUP-TFII to inhibit NFkappaB stimulated TNFAIP3 may play a role in the observed ability of COUP-TFII to resensitize LCC9 cells to 4-OHT."
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"Tnfaip3 is induced by NF-kappaB signaling as an early response gene and encodes the A20 protein, a ubiquitin modifier that inhibits formation of linear and K63 linked ubiquitin chains on key proteins in the NF-kappaB signaling pathway to provide a negative feedback that terminates further activation of NF-kappaB."
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"Moreover, Tax requires CADM1 for its K63-linked polyubiquitination, NF-κB activation, and inactivation of the NF-κB negative regulatory A20 complex."
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"We show that A20 deficient BMDM display enhanced NF-κB and IRF3 activation in response to RIG-I stimulation by synthetic LMW double stranded RNA."
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"Furthermore, TNFAIP3 is activated by NF-kappaB in response to pro inflammatory signals such as TNF-alpha and can inhibit inflammation and programmed cell death."
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"Up-regulation of the inhibitor of NF-kappaB activation TNFAIP3, also known as A20, in the DM samples, along with its binding partner, TNFAIP3 interacting protein 1 (TNIP1), and RELA suggests a potenti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In a similar scenario, the intracellular ubiquitin editing protein A20 / TNFAIP3 is induced by NF-kappaB activating stimuli and is a key player in the negative regulation of NF-kappaB signaling (Coorn[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TNFAIP3 mRNA and protein are rapidly induced by NF-kappaB and form a critical negative feedback loop to diminish NF-kappaB activity by adding K48 linked ubiquitin chains, removing K63 linked ubiquitin chains, and inhibiting the addition of linear ubiquitin chains to key molecules in the NF-kappaB signaling axis."
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"TNFAIP3 is transcriptionally activated by NF-kappaB, allowing A20 to attenuate NF-kappaB signaling by deubiquitinating and hence inactivating TRAF6, MALT1, and IKKgamma, among other substrates."
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"We analyze the network by means of the model combining a deterministic description for molecular species with large cellular concentrations with two classes of stochastic switches: cell-surface receptor activation by TNFalpha ligand, and IkappaBalpha and A20 genes activation by NF-kappaB molecules."
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"Like TRAF3 -/- B cells ( xref ), A20 -/- B cells display enhanced classical NF-κB activation in response to TLR4 ( xref )."
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"These results suggest that the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state."
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